1-Methylindoline-5-carbonyl chloride | 1378285-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-Methylindoline-5-carbonyl chloride
• 英文别名: 1-methyl-2,3-dihydroindole-5-carbonyl chloride
• CAS: 1378285-07-4
• 化学式: C₁₀H₁₀ClNO
• 分子量: 195.648
• InChiKey: MOUUGFNSTNVGID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methylindoline-5-carbonyl chloride 、 2,6-二氟-3-胺基吡啶 在 吡啶 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 生成 5-fluoro-2-(1-methyl-2,3-dihydro-1H-indol-5-yl)oxazolo[5,4-b]pyridine
  参考文献：
  名称：

  Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328

  摘要：

  5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential F-18 containing beta-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having favorable potency versus human beta-amyloid plaque and were radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. These studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of beta-amyloid plaque load.

  DOI：

  10.1021/ml200018n
• 作为产物：
  描述：

  1-甲基吲哚啉-5-羧酸 在 1-氯-N,N,2-三甲基丙烯胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 1-Methylindoline-5-carbonyl chloride
  参考文献：
  名称：

  Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328

  摘要：

  5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential F-18 containing beta-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having favorable potency versus human beta-amyloid plaque and were radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. These studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of beta-amyloid plaque load.

  DOI：

  10.1021/ml200018n

文献信息

• Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-<i>b</i>]pyridines as β-Amyloid PET Ligands and Identification of MK-3328
  作者：Scott T. Harrison、James Mulhearn、Scott E. Wolkenberg、Patricia J. Miller、Stacey S. O’Malley、Zhizhen Zeng、David L. Williams、Eric D. Hostetler、Sandra Sanabria-Bohórquez、Linda Gammage、Hong Fan、Cyrille Sur、J. Christopher Culberson、Richard J. Hargreaves、Jacquelynn J. Cook、George D. Hartman、James C. Barrow

  DOI：10.1021/ml200018n

  日期：2011.7.14

  5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential F-18 containing beta-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having favorable potency versus human beta-amyloid plaque and were radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. These studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of beta-amyloid plaque load.