3-(3,5-dichlorophenyl)-4-chloro-1H-pyrazole | 154257-73-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(3,5-dichlorophenyl)-4-chloro-1H-pyrazole
• 英文别名: 4-chloro-3-(3,5-dichloro)phenylpyrazole；4-chloro-3-(3,5-dichlorophenyl)-1H-pyrazole；4-chloro-5-(3,5-dichlorophenyl)-1H-pyrazole
• CAS: 154257-73-5
• 化学式: C₉H₅Cl₃N₂
• 分子量: 247.511
• InChiKey: GNZJYPDFBXXVEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(3,5-dichlorophenyl)-4-chloro-1H-pyrazole 在 盐酸 、 乙醚 作用下， 以 乙醚 为溶剂， 以to give 1.1 g (yield 52%, melting point: 175° C.) of 4-chloro-3-(3,5-dichlorophenyl)pyrazole hemihydrochloride的产率得到4-Chloro-3-(3,5-dichlorophenyl)pyrazole hemihydrochloride
  参考文献：
  名称：

  Fungicidal arylpyrazoles

  摘要：

  本发明涉及公式（I）的3-芳基吡唑家族的新衍生物，它们的制备方法，包含它们的组合物以及它们在植物保护中对抗真菌病的应用。 ##STR1##

  公开号：

  US05945382A1
• 作为产物：
  描述：

  3’,5’-二氯苯乙酮 在 N-氯代丁二酰亚胺 、 一水合肼 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 100.0h， 生成 3-(3,5-dichlorophenyl)-4-chloro-1H-pyrazole
  参考文献：
  名称：

  The structure of the agrochemical fungicidal 4-chloro-3-(3,5-dichlorophenyl)-1H-pyrazole (RPA 406194) and related compounds

  摘要：

  The difficulties to obtain convenient monocrystals of the important fungicide RPA 406194 have been overcome by a combination of solid state C-13 NMR, X-ray powder diffraction and molecular modeling. The compound, a 3-aryl tautomer, crystallizes forming infinite chains of molecules bonded by N-H...N hydrogen bonds, leading to needle-shaped crystals. The tautomerism (equilibrium constant and energy barrier) of this compound in solution has been studied. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01487-4

文献信息

• [EN] PEHAM DENDRIMERS FOR USE IN AGRICULTURE<br/>[FR] DENDRIMÈRES POLYÉTHER-HYDROXYLAMINE (PEHAM) DESTINÉS À ÊTRE UTILISÉS EN AGRICULTURE
  申请人：DENDRITIC NANOTECHNOLOGIES INC

  公开号：WO2011053605A1

  公开（公告）日：2011-05-05

  Specific PEHAM dendrimers are used in a formulation with an active agent for agricultural purposes, particularly for increasing the efficacy of the active agent in various ways, such as by improving solubility of the active agent in the formulation, by improving adhesion and penetration of the active agent to plant surfaces, by improving the water- fastness of the active agent to the plant or seed, by providing protection of the active agent from UV damage, by increasing soil penetration of the active agent to reach the plant roots or under soil parts, or by reducing soil adhesion of the active agent to reach the plant roots or under soil parts, or reducing enzymatic degradation of the active agent by the plant or seed or microorganisms in the soil.

  特定的PEHAM树枝状聚合物与活性剂配方一起用于农业目的，特别是通过多种方式增加活性剂的功效，比如改善配方中活性剂的溶解性，改善活性剂对植物表面的粘附和渗透性，改善活性剂对植物或种子的耐水性，提供对活性剂免受紫外线损伤的保护，增加活性剂在土壤中的渗透性以达到植物根部或土壤下部，或通过减少活性剂与土壤的粘附以达到植物根部或土壤下部，或减少植物或种子或土壤中微生物对活性剂的酶降解。
• [EN] AGROCHEMICAL DELIVERY SYSTEM BASED ON ENZYME- OR pH- RESPONSIVE AMPHIPHILIC PEG-DENDRON HYBRIDS<br/>[FR] SYSTÈME D'ADMINISTRATION AGROCHIMIQUE BASÉ SUR DES HYBRIDES PEG-DENDRON AMPHIPHILES RÉAGISSANT AUX ENZYMES OU AU PH
  申请人：UNIV RAMOT

  公开号：WO2016038596A1

  公开（公告）日：2016-03-17

  The present invention relates to an amphiphilic hybrid delivery system in micellar form for delivery of agrochemicals, based on a hydrophilic polyethylene glycol (PEG) polymer conjugated to a hydrophobic dendron, the dendron comprising at least one pH-dependent or enzymatically cleavable hydrophobic end group that is covalently attached to the dendron, wherein the micelle disassembles upon enzymatic or pH-dependent cleavage of the hydrophobic end group. The hydrophobic end group that is conjugated to the dendron may comprise an agrochemical, and/or the micelle may (non-covalently) encapsulate an agrochemical. The present invention further provides methods of use thereof and to a kit comprising same.

  本发明涉及一种用于传递农药的两性混合递送系统，基于一种亲水性聚乙二醇（PEG）聚合物与一种疏水性树状结构（dendron）共轭的微胶束形式，其中该树状结构包含至少一个依赖于pH或酶可切割的疏水性末端基团，该末端基团与树状结构共价结合，微胶束在酶切或依赖于pH的条件下解离。与树状结构共轭的疏水性末端基团可能包含一种农药，和/或微胶束可能（非共价地）封装一种农药。本发明还提供了使用方法以及包含相同的试剂盒。
• Arylpyrazole fungicides
  申请人：Rhone-Poulenc Agrochimie

  公开号：US05739153A1

  公开（公告）日：1998-04-14

  3-arylpyrazole derivatives of the formula ##STR1## in which X.sub.1, X.sub.2, X.sub.3, X.sub.4 and X.sub.5, which are the same or different, are H, Hal, nitro, alkyl, alkoxy, Y is H, Hal, nitro, CN, alkyl, alkoxy, alkylthio or an optionally substituted amino; Ra is H, R(alkyl, phenyl, Het), C(V)-V'Ro or C(V)NR.sub.0 R'.sub.0 where: V and V' are O, S; R.sub.0 and R'.sub.0, H, R, R' optionally substituted by .alpha., which can be GR.sub.1, NZ.sub.1 Z.sub.2, SO.sub.2 NZ.sub.1 Z.sub.2, CVZ.sub.1 Z.sub.2, Rb is H or can form with Ra a hydrocarbon ring of 4-6 C, R.sub.1 and R.sub.2 are H, R.sub.0, R.sub.3, G1-T1-Rc, C(O)R.sub.0, NTT'. Said fungicides are useful in agriculture.

  该公式的3-芳基吡唑衍生物为##STR1##其中X.sub.1、X.sub.2、X.sub.3、X.sub.4和X.sub.5，它们可以相同也可以不同，是H、卤素、硝基、烷基、烷氧基，Y为H、卤素、硝基、CN、烷基、烷氧基、烷硫基或可选择取代的氨基；Ra为H、R(烷基、苯基、杂环基)、C(V)-V'Ro或C(V)NR.sub.0 R'.sub.0其中：V和V'为O、S；R.sub.0和R'.sub.0、H、R、R'可选择通过α取代，可能是GR.sub.1、NZ.sub.1 Z.sub.2、SO.sub.2 NZ.sub.1 Z.sub.2、CVZ.sub.1 Z.sub.2，Rb为H或者可以与Ra形成4-6个碳的碳氢环，R.sub.1和R.sub.2为H、R.sub.0、R.sub.3、G1-T1-Rc、C(O)R.sub.0、NTT'。这些杀菌剂在农业中很有用。
• Fungicidal composition and use of this composition for controlling plant diseases
  申请人：——

  公开号：US20040167144A1

  公开（公告）日：2004-08-26

  The present invention relates to a fungicidal composition comprising at least one fungicidal compound of the family of anilinopyrimidines and imazalil, and the use of such a composition combining these active compounds for controlling plant diseases or the phytopathogenic fungi present or capable of appearing on plants.

  本发明涉及一种杀菌组合物，该组合物包含至少一种苯胺嘧啶类和咪唑嘧啶类杀菌化合物，以及使用这种组合物结合这些活性化合物来防治植物病害或植物上存在或可能出现的植物病原真菌。
• Fungicidal composition comprising pyrimethanil and iprodione
  申请人：——

  公开号：US20040235874A1

  公开（公告）日：2004-11-25

  The present invention relates to a novel fungicidal composition comprising pyrimethanil and iprodione in a ratio ranging from 1/3 to 3, and the use of such a composition for controlling particular plant diseases or for controlling specific phytopathogenic fungi present or capable of appearing on plants.

  本发明涉及一种新型杀菌组合物，该组合物由嘧菌酯和异丙双脒组成，两者的比例为 1/3 至 3，本发明还涉及使用这种组合物防治特定植物病害或防治植物上存在或可能出现的特定植物病原真菌。