cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methanone | 1073428-50-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methanone
• 英文别名: cyclopropyl-[6-(trifluoromethyl)pyridin-3-yl]methanone
• CAS: 1073428-50-8
• 化学式: C₁₀H₈F₃NO
• 分子量: 215.175
• InChiKey: FMJBLDLBVVHUAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methanone 在 盐酸 、 titanium(IV) tetraethanolate 、 乙醇 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 生成 (S)-cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methanamine
  参考文献：
  名称：

  WO2008/123963

  摘要：

  公开号：
• 作为产物：
  描述：

  6-三氟甲基烟酰氯 在 吡啶 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 cyclopropyl(6-(trifluoromethyl)pyridin-3-yl)methanone
  参考文献：
  名称：

  WO2008/123963

  摘要：

  公开号：

文献信息

• 2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
  申请人：Wei Zhi-Liang

  公开号：US20080275037A1

  公开（公告）日：2008-11-06

  Fused heterocyclic compounds are provided according to formula 1: where R 1 , R 2 , R 3 , and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  根据公式1提供了融合的杂环化合物：其中R1、R2、R3和m的定义如本文所述。提供的化合物及其药物组合物对于预防和治疗包括人类在内的哺乳动物的多种疾病状况是有用的，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• Direct Aldehyde C–H Arylation and Alkylation via the Combination of Nickel, Hydrogen Atom Transfer, and Photoredox Catalysis
  作者：Xiaheng Zhang、David W. C. MacMillan

  DOI：10.1021/jacs.7b07078

  日期：2017.8.23

  A mechanism that enables direct aldehyde C–H functionalization has been achieved via the synergistic merger of photoredox, nickel, and hydrogen atom transfer catalysis. This mild, operationally simple protocol transforms a wide variety of commercially available aldehydes, along with aryl or alkyl bromides, into the corresponding ketones in excellent yield. This C–H abstraction coupling technology has

  通过光氧化还原，镍和氢原子转移催化的协同合并，已经实现了使醛C–H直接官能化的机制。这种温和的，操作简单的方案以优异的收率将多种市售醛与芳基或烷基溴一起转化为相应的酮。这项C–H抽象偶联技术已成功地应用于合成药物氟哌啶醇的权宜之计。
• 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSTIONS AND USES THEREOF
  申请人：WEI Zhi-Liang

  公开号：US20120149700A1

  公开（公告）日：2012-06-14

  Fused heterocyclic compounds are provided according to formula 1: where R 1 , R 2 , R 3 , and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1定义的熔合杂环化合物：其中R1、R2、R3和m如本文所定义。所提供的化合物及其制剂对于哺乳动物，包括人类的多种病症的预防和治疗有用，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• 2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof
  申请人：Evotec AG

  公开号：US08076345B2

  公开（公告）日：2011-12-13

  Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1定义的融合杂环化合物，其中R1、R2、R3和m如本文所定义。所提供的化合物及其制剂在哺乳动物中，包括人类中，用于预防和治疗多种疾病，例如但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof
  申请人：Wei Zhi-Liang

  公开号：US08653091B2

  公开（公告）日：2014-02-18

  Fused heterocyclic compounds are provided according to formula 1a or 1b: where R1, R2, and R3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1a或1b提供的融合杂环化合物：其中R1、R2和R3如本文所定义。所提供的化合物及其制药组合物对于哺乳动物，包括人类的预防和治疗各种疾病是有用的，包括但不限于疼痛，炎症，认知障碍，焦虑，抑郁等。