9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol | 118201-22-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol
• 英文别名: 2,5-Dimethoxy-9,10-dihydrophenanthrene-1,7-diol
• CAS: 118201-22-2
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: YSSFIGREEVEYNI-UHFFFAOYSA-N

物化性质

• 沸点：
  502.4±50.0 °C(Predicted)
• 密度：
  1.290±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol 生成 (8-acetyloxy-4,7-dimethoxy-9,10-dihydrophenanthren-2-yl) acetate
  参考文献：
  名称：

  TUCHINDA, PATOOMRATANA;UDCHACHON, JINDA;KHUMTAVEEPORN, KANJAI;TAYLOR, WAL+, PHYTOCHEMISTRY, 27,(1988) N 10, C. 3267-3271

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苄氧基-3-甲氧基苯甲醛 在 sodium tetrahydroborate 、 偶氮二异丁腈 、 palladium 10% on activated carbon 、 lithium methanolate 、 氢气 、 三正丁基氢锡 、 三溴化磷 作用下， 以 甲烷磺酸 、 乙醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 异丙醇 、 甲苯 为溶剂， 110.0 ℃ 、482.64 kPa 条件下， 反应 36.0h， 生成 9,10-dihydro-2,5-dimethoxyphenanthrene-1,7-diol
  参考文献：
  名称：

  Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential

  摘要：

  Regioselective synthesis of 9,10-Dihydro-2,5-Dimethoxyphenanthrene-1,7-diol (1) and 9,10-Dihydro-2,7-Dimethoxyphenanthrene-1,5-diol (2) was achieved using regioselective methylation, Wittig reaction, intramolecular cyclization and hydrogenation as key steps. The synthesis was successfully completed in total of 15 steps with 3.3% overall yield in case of 1 and in total of 13 steps with 9.0% overall yield in case of 2. All compounds (1-4) showed good antioxidant and anti-inflammatory activity in in vitro assays and these activities were found to be due the presence of phenolic hydroxyl groups. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.06.016

文献信息

• Functional foods and beverages with synergistic properties to promote homeostasis
  申请人：JUSTBIO INC.

  公开号：US10028990B2

  公开（公告）日：2018-07-24

  The present invention provides compositions having synergistic antioxidant properties in the modulation of Toll-like receptor signaling for the promotion of homeostasis, immunity, energy conservation, protection of neural cells and anti-inflammatory responses, said compositions comprising plant and/or fruit extracts and a natural sweetener with high oxidation potential as defined by ORAC value.

  本发明提供了在调节 Toll 样受体信号以促进平衡、免疫、能量保存、保护神经细胞和抗炎反应方面具有协同抗氧化特性的组合物，所述组合物包括植物和/或水果提取物以及一种根据 ORAC 值定义的具有高氧化潜能的天然甜味剂。
• FUNCTIONAL FOODS AND BEVERAGES WITH SYNERGISTIC PROPERTIES TO PROMOTE HOMEOSTASIS
  申请人：Justbio Inc.

  公开号：EP2670415A1

  公开（公告）日：2013-12-11
• Thiazolidine Linker for the Conjugation of Drugs to Antibodies
  申请人：Philogen S.P.A.

  公开号：US20130309257A1

  公开（公告）日：2013-11-21

  In one aspect, there is provided a protein-drug conjugate compound comprising a protein covalently attached by a linker to one or more drug moieties, wherein the linker has a half-life of from 1 hour to 50 hours in phosphate buffered saline at 37° C. A carbonyl derivative of LU103793 is also described that can be used in a protein-drug conjugate compound comprising an antibody covalently attached by a linker to the drug moiety comprising, consisting or consisting essentially of the carbonyl derivative.
• COMBINATION COMPRISING PARTHENOLIDE FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS
  申请人：King Abdullah University of Science and Technology

  公开号：US20150164858A1

  公开（公告）日：2015-06-18

  The present invention generally concerns particular methods and compositions for treatment of a neurodegenerative disease, such as Alzheimer's Disease. In particular embodiments, there is a composition comprising Parthenolide and a second agent, including an inhibitor of TLR4/MD-2/CD14, nAChR agonist, Resatorvid, Curcumin, Tilorone or a Tilorone analog, or a combination thereof.
• US9198979B2
  申请人：——

  公开号：US9198979B2

  公开（公告）日：2015-12-01