juniperonic acid | 18016-45-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: juniperonic acid
• 英文别名: (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenoic acid
• CAS: 18016-45-0
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: JDKIKEYFSJUYJZ-OUJQXAOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  22
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

ADMET

代谢

浆果树酸是二十碳五烯酸的一种已知人类代谢物。

Juniperonic acid is a known human metabolite of eicosapentaenoic acid.

来源:NORMAN Suspect List Exchange

反应信息

• 作为反应物：
  描述：

  juniperonic acid 、 3-吡啶甲醇 、 4-吡咯烷基吡啶 、 N,N'-羰基二咪唑 、 二氯甲烷 生成 Picolinyl 5,11,14,17-eicosatetraenoate
  参考文献：
  名称：

  LIE, KEN JIE MARCEL S. F.;CHOI, CANDY Y. C.;BERGER, A.;BERGER, R. G., J. CHROMATOGR., 543,(1991) N, C. 257-261

  摘要：

  DOI：
• 作为产物：
  描述：

  (5Z,11Z,14Z,17Z)-icosa-5,11,14,17-tetraenal 在 sodium chlorite 、 sodium dihydrogenphosphate 、 2-甲基-2-丁烯 作用下， 以 水 、 乙腈 为溶剂， 以86%的产率得到juniperonic acid
  参考文献：
  名称：

  Synthesis of juniperonic acid

  摘要：

  Synthesis of juniperonic acid [(all-Z)-5,11,14,17-eicosatetraenoic acid], has been achieved in eight steps and in 19% overall yield starting from eicosapentaenoic acid. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.085

文献信息

• ANTI-INFLAMMATORY AGENT CONTAINING RARE FATTY ACID
  申请人：Kyoto University

  公开号：EP3097910A1

  公开（公告）日：2016-11-30

  The present invention provides an anti-inflammatory agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the anti-inflammatory agent.

  本发明提供了一种含有稀有脂肪酸（如羟化脂肪酸、氧代脂肪酸等）的消炎剂，以及含有该消炎剂的食品、药品等。
• METABOLISM-IMPROVING AGENT COMPRISING RARE FATTY ACID
  申请人：Kyoto University

  公开号：EP3097911A1

  公开（公告）日：2016-11-30

  The present invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

  本发明提供了一种含有稀有脂肪酸（如羟化脂肪酸、氧代脂肪酸等）的新陈代谢促进剂，以及含有该新陈代谢促进剂的食品、药品等。
• METHOD FOR PRODUCING RARE FATTY ACID USING NOVEL ENZYME, AND NOVEL RARE FATTY ACID
  申请人：Kyoto University

  公开号：EP3098313A1

  公开（公告）日：2016-11-30

  The present invention provides production of hydroxylated fatty acid by a hydration reaction using a novel enzyme derived from lactobacillus and using fatty acid as a substrate, and further, a production method of oxo fatty acid by an enzyme reaction or chemical oxidation reaction using the hydroxylated fatty acid as a substrate. In addition, a valuable novel rare fatty acid obtained by such production method is also provided.

  本发明提供了一种以脂肪酸为底物，使用源自乳酸杆菌的新型酶，通过水合反应生产羟基化脂肪酸的方法，并进一步提供了一种以羟基化脂肪酸为底物，通过酶反应或化学氧化反应生产氧化脂肪酸的方法。此外，还提供了通过这种生产方法获得的有价值的新型稀有脂肪酸。
• SN-1(3) MONOACYLGLYCERIDES AND LIPID ABSORPTION
  申请人：Nestec S.A.

  公开号：EP3135283A1

  公开（公告）日：2017-03-01

  The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising sn-1(3) monoacylglycerols, wherein the sn-1 or sn-3 position is occupied by an acyl group such as a fatty acid and the sn-2 position remains unoccupied. The fatty acid may be one with anti-inflammatory properties.

  本发明一般涉及脂质领域，尤其旨在改善脂质的吸收，例如在脂质消化不良或吸收不良的情况下。本发明的一个实施方案涉及一种包含 sn-1(3)单酰基甘油的组合物，其中 sn-1 或 sn-3 位置被脂肪酸等酰基占据，而 sn-2 位置未被占据。脂肪酸可以是具有抗炎特性的脂肪酸。
• Metabolism-improving agent comprising rare fatty acid
  申请人：KYOTO UNIVERSITY

  公开号：US10548868B2

  公开（公告）日：2020-02-04

  The present invention provides a metabolism improving agent containing a rare fatty acid such as hydroxylated fatty acid, oxo fatty acid and the like, and further, food, pharmaceutical product and the like containing the metabolism improving agent.

  本发明提供了一种含有稀有脂肪酸（如羟化脂肪酸、氧代脂肪酸等）的新陈代谢促进剂，以及含有该新陈代谢促进剂的食品、药品等。