methyl (2S,4R)-1-(2-azido-4,5-dimethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylate | 382137-66-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S,4R)-1-(2-azido-4,5-dimethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylate
• CAS: 382137-66-8
• 化学式: C₁₅H₁₈N₄O₆
• 分子量: 350.331
• InChiKey: LGRJLFMQZWVOQK-KCJUWKMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  99.7
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  methyl (2S,4R)-1-(2-azido-4,5-dimethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylate 在 三氟化硼乙醚 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 1.2h， 以78%的产率得到(11aS)-2(R)-hydroxy-7,8-dimethoxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine
  参考文献：
  名称：

  使用 BF3·OEt2/NaI 将芳族叠氮化物有效选择性还原为胺：吡咯并苯二氮卓类化合物的合成

  摘要：

  使用三氟化硼乙醚合物和碘化钠将芳族叠氮化物还原为胺的选择性和简便方法。该方法已应用于通过分子内还原环化过程制备具有生物学意义的含亚胺的吡咯并苯二氮卓类及其双内酰胺。在该协议中，试剂系统适用于生成溶液相组合合成。

  DOI：

  10.1055/s-2008-1072742
• 作为产物：
  描述：

  反式-4-羟基-L-脯氨酸甲酯盐酸盐 、 2-azido-4,5-dimethoxybenzoic acid 在 氯化亚砜 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 methyl (2S,4R)-1-(2-azido-4,5-dimethoxybenzoyl)-4-hydroxypyrrolidine-2-carboxylate
  参考文献：
  名称：

  Selective reduction of aromatic azides with hexamethyldisilathiane: synthesis of new 2-azidopyrrolo[2,1-c][1,4]benzodiazepines

  摘要：

  2-Azidopyrrolobenzodiazepines have been synthesized via cyclization of omega-azidocarbonyl compounds employing hexamethyldisilathiane by selectively reducing the aryl azido functionality. (C) 2004 Elsevier Ltd. All right reserved.

  DOI：

  10.1016/j.tetlet.2004.02.148

文献信息

• Selective reduction of aromatic azides in solution/solid-phase and resin cleavage by employing BF3·OEt2/EtSH. Preparation of DC-81
  作者：Ahmed Kamal、N. Shankaraiah、K. Laxma Reddy、V. Devaiah

  DOI：10.1016/j.tetlet.2006.04.025

  日期：2006.6

  An efficient method for the reduction of aromatic azides in both solution and solid-phase has been developed by employing (BF3OEt2)-O-./EtSH. This report also describes resin cleavage employing this reagent system. Further, this protocol has been utilized for the solution as well as the solid-phase synthesis of pyrrolo[2, 1-c][1,4]benzodiazepines, including the naturally occurring antibiotic DC-81 and fused [2,1-b]quinazolinones. (c) 2006 Elsevier Ltd. All rights reserved.
• Efficient reduction of aromatic nitro/azido groups on solid support employing indium: synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones
  作者：Ahmed Kamal、G.Suresh Kumar Reddy、K.Laxma Reddy

  DOI：10.1016/s0040-4039(01)01435-6

  日期：2001.9

  An efficient method for the reduction of aromatic nitro and azido compounds on solid support using indium/NH4Cl is described. This solid-phase reduction technique has been applied to the synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones (C) 2001 Elsevier Science Ltd. All rights reserved.
• Selective reduction of aromatic azides with hexamethyldisilathiane: synthesis of new 2-azidopyrrolo[2,1-c][1,4]benzodiazepines
  作者：Ahmed Kamal、K.Laxma Reddy、G.Suresh Kumar Reddy、B.S.Narayan Reddy

  DOI：10.1016/j.tetlet.2004.02.148

  日期：2004.4

  2-Azidopyrrolobenzodiazepines have been synthesized via cyclization of omega-azidocarbonyl compounds employing hexamethyldisilathiane by selectively reducing the aryl azido functionality. (C) 2004 Elsevier Ltd. All right reserved.
• An Efficient Selective Reduction of Aromatic Azides to Amines Employing BF₃·OEt₂/NaI: Synthesis of Pyrrolobenzodiazepines
  作者：Ahmed Kamal、Ch. Reddy、N. Shankaraiah、N. Markandeya

  DOI：10.1055/s-2008-1072742

  日期：2008.5

  A selective and facile method for the reduction of aromatic azides to amines by employing borontrifluoride diethyl etherate and sodium iodide. This methodology has been applied towards the preparation of biologically important imine-containing pyrrolobenzodiazepines and their dilactams through intramolecular reductive-cyclization process. In this protocol the reagent systems are amenable for the generation

  使用三氟化硼乙醚合物和碘化钠将芳族叠氮化物还原为胺的选择性和简便方法。该方法已应用于通过分子内还原环化过程制备具有生物学意义的含亚胺的吡咯并苯二氮卓类及其双内酰胺。在该协议中，试剂系统适用于生成溶液相组合合成。