(((2R,3S)-3-azido-5-(benzyloxy)-2-methylpentyl)oxy)(tert-butyl)diphenylsilane | 934400-65-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (((2R,3S)-3-azido-5-(benzyloxy)-2-methylpentyl)oxy)(tert-butyl)diphenylsilane
• CAS: 934400-65-4
• 化学式: C₂₉H₃₇N₃O₂Si
• 分子量: 487.717
• InChiKey: DJYGXZAANZBWPU-CUBQBAPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.48
• 重原子数：
  35.0
• 可旋转键数：
  12.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.22
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (((2R,3S)-3-azido-5-(benzyloxy)-2-methylpentyl)oxy)(tert-butyl)diphenylsilane 在 platinum(IV) oxide 、 palladium on activated charcoal 吡啶 、 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 lithium hydroxide 、 sodium hypochlorite 、 sodium chlorite 、 草酰氯 、 free radical 、 五氟苯基二苯基磷酸酯 、 氢氟酸 、 氢气 、 1-羟基苯并三唑 、 二甲基亚砜 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 phosphate buffer 、 乙醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 101.83h， 生成 (-)-azumamide E
  参考文献：
  名称：

  Molecular Insights into Azumamide E Histone Deacetylases Inhibitory Activity

  摘要：

  Azumamide E, a cyclotetrapeptide isolated from the sponge Mycale izuensis, is the most powerful carboxylic acid containing natural histone deacetylase (HDAC) inhibitor known to date. In this paper, we describe design and synthesis of two stereochemical variants of the natural product. These compounds have allowed us to clarify the influence of side chain topology on the HDAC-inhibitory activity. The present contribution also reveals the identity of the recognition pattern between azumamides and the histone deacetylase-like protein (HDLP) model receptor and reports the azumamide E unprecedented isoform selectivity on histone deacetylases class subtypes. From the present studies, a plausible model for the interaction of azumamides with the receptor binding pocket is derived, providing a framework for the rational design of new cyclotetrapeptide-based HDAC inhibitors as antitumor agents.

  DOI：

  10.1021/ja0686256
• 作为产物：
  描述：

  3-苄氧基丙醛 在 吡啶 吡啶 、 4-二甲氨基吡啶 、 sodium azide 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 (((2R,3S)-3-azido-5-(benzyloxy)-2-methylpentyl)oxy)(tert-butyl)diphenylsilane
  参考文献：
  名称：

  Molecular Insights into Azumamide E Histone Deacetylases Inhibitory Activity

  摘要：

  Azumamide E, a cyclotetrapeptide isolated from the sponge Mycale izuensis, is the most powerful carboxylic acid containing natural histone deacetylase (HDAC) inhibitor known to date. In this paper, we describe design and synthesis of two stereochemical variants of the natural product. These compounds have allowed us to clarify the influence of side chain topology on the HDAC-inhibitory activity. The present contribution also reveals the identity of the recognition pattern between azumamides and the histone deacetylase-like protein (HDLP) model receptor and reports the azumamide E unprecedented isoform selectivity on histone deacetylases class subtypes. From the present studies, a plausible model for the interaction of azumamides with the receptor binding pocket is derived, providing a framework for the rational design of new cyclotetrapeptide-based HDAC inhibitors as antitumor agents.

  DOI：

  10.1021/ja0686256