(E)-3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one | 1239732-69-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one
• 英文别名: (E)-3-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]-1-(4-methoxyphenyl)prop-2-en-1-one
• CAS: 1239732-69-4
• 化学式: C₂₅H₁₉ClN₂O₂
• 分子量: 414.891
• InChiKey: FYSDRTSQVDPCRN-LFIBNONCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E)-3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one 、 溶剂黄146 在 一水合肼 作用下， 反应 0.08h， 以92%的产率得到1-acetyl-5-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
  参考文献：
  名称：

  Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

  摘要：

  Novel (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 5/6 (pyrazolic chalcones) were synthesized from a Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 1. Subsequently, the microwave-assisted cyclocondensation reaction of chalcones 5/6 with hydrazine afforded the new racemic 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7 or their N-acetyl derivatives 8 and 9 when reactions where carried out in DMF or acetic acid, respectively. Several of these compounds were screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines, where 5c and 9g showed remarkable activity mainly against leukemia (K-562 and SR), renal cancer (UO-31) and non-small cell lung cancer (HOP-92) cell lines, with the most important GI(50) values ranging from 0.04 to 11.4 mu M, from the in vitro assays. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.06.013
• 作为产物：
  描述：

  N-(4-chlorobenzylidene)-N'-phenylhydrazine 在 sodium hydroxide 、 三氯氧磷 作用下， 反应 5.25h， 生成 (E)-3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)-1-(4-methoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study

  摘要：

  A series of pyrazole-pyrazoline substituted with benzenesulfonamide were synthesized and evaluated for their antimalarial activity in vitro and in vivo. The compounds were active against both chloroquine (CQ) sensitive (3D7) and CQ resistant (RKL-9) strains of Plasmodium falciparum. Seven compounds (7e, 7i, 7j, 7l, 7m, 7o and 7p) exhibiting EC50 less than 2 mu M. A mechanistic study of compound 7o revealed that these compound act through the inhibition of beta-hematin. The study indicated that these compounds can serve as lead compounds for further development of potent antimalarial drugs. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.01.082

文献信息

• PYRAZOLYLACYLPYRAZOLINE COMPOUNDS AND METHOD FOR TREATING PAIN
  申请人：THE TRUSTEES OF INDIANA UNIVERSITY

  公开号：US20210155609A1

  公开（公告）日：2021-05-27

  This invention relates to pyrazolylacylpyrazoline compounds or pharmaceutically acceptable salts thereof, and for the use of the compounds to treat neurological disorders.

  这项发明涉及吡唑基酰基吡唑啉化合物或其药用盐，以及利用这些化合物治疗神经系统疾病。
• Pyrazole-pyrazoline as promising novel antimalarial agents: A mechanistic study
  作者：Gautam Kumar、Omprakash Tanwar、Jitender Kumar、Mymoona Akhter、Supriya Sharma、C.R. Pillai、Md Mumtaz Alam、M.S. Zama

  DOI：10.1016/j.ejmech.2018.01.082

  日期：2018.4

  A series of pyrazole-pyrazoline substituted with benzenesulfonamide were synthesized and evaluated for their antimalarial activity in vitro and in vivo. The compounds were active against both chloroquine (CQ) sensitive (3D7) and CQ resistant (RKL-9) strains of Plasmodium falciparum. Seven compounds (7e, 7i, 7j, 7l, 7m, 7o and 7p) exhibiting EC50 less than 2 mu M. A mechanistic study of compound 7o revealed that these compound act through the inhibition of beta-hematin. The study indicated that these compounds can serve as lead compounds for further development of potent antimalarial drugs. (C) 2018 Elsevier Masson SAS. All rights reserved.
• Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents
  作者：Braulio Insuasty、Alexis Tigreros、Fabián Orozco、Jairo Quiroga、Rodrigo Abonía、Manuel Nogueras、Adolfo Sanchez、Justo Cobo

  DOI：10.1016/j.bmc.2010.06.013

  日期：2010.7

  Novel (E)-1-aryl-3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)prop-2-en-1-ones 5/6 (pyrazolic chalcones) were synthesized from a Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives 1. Subsequently, the microwave-assisted cyclocondensation reaction of chalcones 5/6 with hydrazine afforded the new racemic 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazoles 7 or their N-acetyl derivatives 8 and 9 when reactions where carried out in DMF or acetic acid, respectively. Several of these compounds were screened by the US National Cancer Institute (NCI) for their ability to inhibit 60 different human tumor cell lines, where 5c and 9g showed remarkable activity mainly against leukemia (K-562 and SR), renal cancer (UO-31) and non-small cell lung cancer (HOP-92) cell lines, with the most important GI(50) values ranging from 0.04 to 11.4 mu M, from the in vitro assays. (C) 2010 Elsevier Ltd. All rights reserved.