3-[3,5-bis(benzyloxy)-4-bromobenzyloxy]-5-[3,5-bis(benzyloxy)benzyloxy]benzylalcohol | 278610-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-[3,5-bis(benzyloxy)-4-bromobenzyloxy]-5-[3,5-bis(benzyloxy)benzyloxy]benzylalcohol
• 英文别名: [3-[[3,5-Bis(phenylmethoxy)phenyl]methoxy]-5-[[4-bromo-3,5-bis(phenylmethoxy)phenyl]methoxy]phenyl]methanol
• CAS: 278610-82-5
• 化学式: C₄₉H₄₃BrO₇
• 分子量: 823.78
• InChiKey: PVNFGWPNNVOUQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  57
• 可旋转键数：
  19
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-[3,5-bis(benzyloxy)-4-bromobenzyloxy]-5-[3,5-bis(benzyloxy)benzyloxy]benzylalcohol 在 四溴化碳 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以99%的产率得到3-[3,5-bis(benzyloxy)-4-bromobenzyloxy]-5-[3,5-bis(benzyloxy)benzyloxy]benzylbromide
  参考文献：
  名称：

  A Facile Synthetic Route to a Third-Generation Dendrimer with Generation-Specific Functional Aryl Bromides

  摘要：

  [GRAPHICS]The synthesis of three third-generation dendrimers that selectively carry one aryl bromide functional group in the first, second, or third generation, respectively, is described. These functions, regardless of their location, can be chemically modified by Suzuki cross-coupling chemistry with p-Tert-butylbenzene boronic ester.

  DOI：

  10.1021/ol005972q
• 作为产物：
  描述：

  4-溴-3,5-二羟基苯甲酸甲酯 在 锂硼氢 、 四溴化碳 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 56.0h， 生成 3-[3,5-bis(benzyloxy)-4-bromobenzyloxy]-5-[3,5-bis(benzyloxy)benzyloxy]benzylalcohol
  参考文献：
  名称：

  A Facile Synthetic Route to a Third-Generation Dendrimer with Generation-Specific Functional Aryl Bromides

  摘要：

  [GRAPHICS]The synthesis of three third-generation dendrimers that selectively carry one aryl bromide functional group in the first, second, or third generation, respectively, is described. These functions, regardless of their location, can be chemically modified by Suzuki cross-coupling chemistry with p-Tert-butylbenzene boronic ester.

  DOI：

  10.1021/ol005972q

文献信息

• A Facile Synthetic Route to a Third-Generation Dendrimer with Generation-Specific Functional Aryl Bromides
  作者：Zhishan Bo、Andreas Schäfer、Peter Franke、A. Dieter Schlüter

  DOI：10.1021/ol005972q

  日期：2000.6.1

  [GRAPHICS]The synthesis of three third-generation dendrimers that selectively carry one aryl bromide functional group in the first, second, or third generation, respectively, is described. These functions, regardless of their location, can be chemically modified by Suzuki cross-coupling chemistry with p-Tert-butylbenzene boronic ester.