6,2',3'-trihydroxyflavone | 108238-47-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6,2',3'-trihydroxyflavone
• 英文别名: 2-(2,3-dihydroxyphenyl)-6-hydroxychromen-4-one；ZINC00057846；2-(2,3-Dihydroxy-phenyl)-6-hydroxy-chromen-4-on
• CAS: 108238-47-7
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: WAOMPPQDRVQLSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,2,2-三氯乙基氯磺酸酯 、 6,2',3'-trihydroxyflavone 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以90%的产率得到
  参考文献：
  名称：

  Synthesis of per-sulfated flavonoids using 2,2,2-trichloro ethyl protecting group and their factor Xa inhibition potential

  摘要：

  The synthesis of per-sulfated flavonoids, organic compounds with multiple sulfate groups, is challenging. We present here a two-step synthesis of fully sulfated flavonoids in high overall yields using the 2,2,2-trichloroethyl moiety as a protecting group. The two-step synthesis results in exclusive formation of the per-sulfated product in contrast to common sulfating agents that yield differentially sulfated mixture of compounds. Most per-sulfated flavonoids studied are activators of antithrombin for accelerated inhibition of factor Xa, a key enzyme of the blood coagulation cascade. As a group the per-sulfated flavonoids possess a range of factor Xa inhibition potential. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.11.060
• 作为产物：
  描述：

  6,2′,3′-trimethoxyflavone 在 氢碘酸 、 乙酸酐 作用下， 生成 6,2',3'-trihydroxyflavone
  参考文献：
  名称：

  Arcoleo et al., Annali di Chimica, 1957, vol. 47, p. 75,80

  摘要：

  DOI：

文献信息

• Pluripotent cell lines and methods of use thereof
  申请人：Parkinson's Institute

  公开号：US10233422B2

  公开（公告）日：2019-03-19

  Methods of generating cell lines with a sequence variation or copy number variation of a gene of interest, methods of use thereof, and cell lines with a sequence variation or copy number variation of a gene of interest are provided.

  提供了产生具有相关基因序列变异或拷贝数变异的细胞系的方法、其使用方法以及具有相关基因序列变异或拷贝数变异的细胞系。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALTERED -SYNUCLEIN FUNCTION
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  公开号：EP2361089A1

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• Compounds exhibiting efflux inhibitor activity and composition and uses thereof
  申请人：Wempe Fitzpatrick Michael

  公开号：US20070254859A1

  公开（公告）日：2007-11-01

  At least one compound chosen from compounds of Formula I: a pharmaceutically acceptable salt or ester thereof, a solvate thereof, a chelate thereof, a non-covalent complex thereof, a prodrug thereof, and mixtures of any of the foregoing, wherein: n is a number from 1 to 900, wherein the individual units may be the same or different; W is chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; each of R 2 , R 3 , R 4 and R 5 is independently chosen from —H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl; Z′ is chosen from —O—, —N—, —NO—, —NR 4 —, —S—, —SO— and —SO 2 —, wherein R 4 is defined as above; each of X, X′, Y and Z is independently chosen from —CR 4 R 5 —, —NH—, —NR 4 —, —NO—, —O—, —NOR 4 —, —S—, —SO—, —SO 2 —, wherein R 4 and R 5 are defined as above; R 1 is chosen from a tocopherol, a steroid and a flavonoid; and R 6 is chosen from any R 1 , alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, substituted aryl, aralkyl and substituted aralkyl.
• METHODS AND COMPOSITIONS FOR TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Langston William J.

  公开号：US20110111014A1

  公开（公告）日：2011-05-12

  Methods and compositions are provided for preventing and treating neurological disorders, in particular Parkinson's disease.
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF ALTERED ALPHA-SYNUCLEIN FUNCTION
  申请人：Manning-Bog Amy B.

  公开号：US20120052053A1

  公开（公告）日：2012-03-01

  Compositions and methods are provided for treating a disorder characterized by α-synuclein dysfunction and/or altered lipid metabolism.