2-(3-Methoxyphenyl)-3-nitrosoimidazo[1,2-a]pyridine | 205655-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-Methoxyphenyl)-3-nitrosoimidazo[1,2-a]pyridine
• 英文别名: 2-(3-methoxyphenyl)-3-nitrosoimidazo[1,2-a]pyridine
• CAS: 205655-28-3
• 化学式: C₁₄H₁₁N₃O₂
• 分子量: 253.26
• InChiKey: ORRJDFODFOSXPD-UHFFFAOYSA-N

物化性质

• 熔点：
  165-167 °C
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  56
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-Methoxyphenyl)-3-nitrosoimidazo[1,2-a]pyridine 在 溶剂黄146 、 锌 作用下， 以 水 为溶剂， 反应 4.0h， 以40%的产率得到2-(3-methoxyphenyl)imidazo[1,2-a]pyridin-3-amine
  参考文献：
  名称：

  Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria

  摘要：

  Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10013-x
• 作为产物：
  描述：

  2-(3-甲氧基苯基)咪唑并[1,2-a]吡啶 在 溶剂黄146 、 sodium nitrite 作用下， 反应 3.0h， 以73%的产率得到2-(3-Methoxyphenyl)-3-nitrosoimidazo[1,2-a]pyridine
  参考文献：
  名称：

  Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria

  摘要：

  Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10013-x

文献信息

• Potential inhibitors of plasmodial heme oxygenase; an innovative approach for combating chloroquine resistant malaria
  作者：Pratima Srivastava、Vikash Chandra Pandey、Anju Prabha Misra、Preeti Gupta、Kanwal Raj、Amiya Prasad Bhaduri

  DOI：10.1016/s0968-0896(97)10013-x

  日期：1998.2

  Syntheses of imidazo-pyridines and substituted prolines and their effect on heme oxygenase activity of Plasmodium yoelii and corresponding infected host have been studied. Six compounds in vitro and one in vivo showed selective inhibition of parasite enzyme which may be further exploited in the development of resistant reversal agents. (C) 1998 Elsevier Science Ltd. All rights reserved.