(1R,4S,4aR,6S)-4,4a-dimethyl-7-oxo-6-(2-oxoethyl)-1,2,3,4,4a,5,6,7-octahydronaphthalen-1-yl decanoate | 852384-66-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (1R,4S,4aR,6S)-4,4a-dimethyl-7-oxo-6-(2-oxoethyl)-1,2,3,4,4a,5,6,7-octahydronaphthalen-1-yl decanoate
• 英文别名: [(1R,4S,4aR,6S)-4,4a-dimethyl-7-oxo-6-(2-oxoethyl)-1,2,3,4,5,6-hexahydronaphthalen-1-yl] decanoate
• CAS: 852384-66-8
• 化学式: C₂₄H₃₈O₄
• 分子量: 390.563
• InChiKey: ITIHRGITHJVUJI-JDKSZYQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1R,4S,4aR,6S)-4,4a-dimethyl-7-oxo-6-(2-oxoethyl)-1,2,3,4,4a,5,6,7-octahydronaphthalen-1-yl decanoate 、 n,n-二甲基亚甲基碘化胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以78%的产率得到(3S,4aR,5S,8R)-8-decanoyloxy-3-[(1-formyl)vinyl]-4a,5-dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one
  参考文献：
  名称：

  Enantioselective Syntheses of (+)-Xylarenal A and ent-Xylarenal A

  摘要：

  The total synthesis of the sesquiterpenoid xylarenal A is reported. This first synthetic entry to an eremophilane terpenoid with an exocyclic vinyl aldehyde unit involves the use of the bicyclic enone (+)-3, which after a gamma-oxidation and alpha '-allylation leads to the formation of the ketone (+)-8. After its acylation, an oxidative cleavage of the allyl side chain followed by alpha-methylenation of the resulting aldehyde gives (+)-xylarenal A (1). The synthesis of (-)-xylarenal A from (-)-3 is also reported. Moreover, the first total synthesis of the trinoreremophilane (+)-1 alpha-hydroxyisoondetianone (5) is described.

  DOI：

  10.1021/jo0502450
• 作为产物：
  描述：

  正癸酸酐 在 2,6-二甲基吡啶 、 4-二甲氨基吡啶 、 sodium periodate 、 四氧化锇 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 反应 28.0h， 生成 (1R,4S,4aR,6S)-4,4a-dimethyl-7-oxo-6-(2-oxoethyl)-1,2,3,4,4a,5,6,7-octahydronaphthalen-1-yl decanoate
  参考文献：
  名称：

  Enantioselective Syntheses of (+)-Xylarenal A and ent-Xylarenal A

  摘要：

  The total synthesis of the sesquiterpenoid xylarenal A is reported. This first synthetic entry to an eremophilane terpenoid with an exocyclic vinyl aldehyde unit involves the use of the bicyclic enone (+)-3, which after a gamma-oxidation and alpha '-allylation leads to the formation of the ketone (+)-8. After its acylation, an oxidative cleavage of the allyl side chain followed by alpha-methylenation of the resulting aldehyde gives (+)-xylarenal A (1). The synthesis of (-)-xylarenal A from (-)-3 is also reported. Moreover, the first total synthesis of the trinoreremophilane (+)-1 alpha-hydroxyisoondetianone (5) is described.

  DOI：

  10.1021/jo0502450

文献信息

• Enantioselective Syntheses of (+)-Xylarenal A and <i>e</i><i>nt</i>-Xylarenal A
  作者：Sandra Díaz、Asensio González、Ben Bradshaw、Javier Cuesta、Josep Bonjoch

  DOI：10.1021/jo0502450

  日期：2005.4.1

  The total synthesis of the sesquiterpenoid xylarenal A is reported. This first synthetic entry to an eremophilane terpenoid with an exocyclic vinyl aldehyde unit involves the use of the bicyclic enone (+)-3, which after a gamma-oxidation and alpha '-allylation leads to the formation of the ketone (+)-8. After its acylation, an oxidative cleavage of the allyl side chain followed by alpha-methylenation of the resulting aldehyde gives (+)-xylarenal A (1). The synthesis of (-)-xylarenal A from (-)-3 is also reported. Moreover, the first total synthesis of the trinoreremophilane (+)-1 alpha-hydroxyisoondetianone (5) is described.