(+/-)-7,3'-dimethoxymethoxy-4'-methoxyflavan | 618896-06-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: (+/-)-7,3'-dimethoxymethoxy-4'-methoxyflavan
• 英文别名: 7-(methoxymethoxy)-2-[4-methoxy-3-(methoxymethoxy)phenyl]-3,4-dihydro-2H-chromene
• CAS: 618896-06-3
• 化学式: C₂₀H₂₄O₆
• 分子量: 360.407
• InChiKey: NVIHTQKYSICELX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (+/-)-7,3'-dimethoxymethoxy-4'-methoxyflavan 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以80%的产率得到(+/-)-7,3'-dihydroxy-4'-methoxyflavan
  参考文献：
  名称：

  Studies on Flavans. III. The Total Synthesis of (±)-7,4′-Dihydroxy-3′-methoxyflavan, (±)-7,3′-Dihydroxy-4′-methoxyflavan, and (±)-7,4′-Dihydroxyflavan

  摘要：

  The first total synthesis of (+/-)-7,3'-dihydroxy-4'-methoxyflavan (1) and (+/-)-7,4'-dihydroxy-3'-methoxyflavan (2), along with the synthesis of (+/-)-7,4'-dihydroxyflavan (3), three naturally occurring flavans, were described. The key step is the cyclization of 1,3-diaryl-1-propanol by (BF3Et2O)-Et-..

  DOI：

  10.1081/scc-120024733
• 作为产物：
  描述：

  1-(4-methoxy-3-methoxymethoxyphenyl)-3-(2,4-dimethoxyphenyl)-1-propanol 在 三氟化硼乙醚 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 以90%的产率得到(+/-)-7,3'-dimethoxymethoxy-4'-methoxyflavan
  参考文献：
  名称：

  Studies on Flavans. III. The Total Synthesis of (±)-7,4′-Dihydroxy-3′-methoxyflavan, (±)-7,3′-Dihydroxy-4′-methoxyflavan, and (±)-7,4′-Dihydroxyflavan

  摘要：

  The first total synthesis of (+/-)-7,3'-dihydroxy-4'-methoxyflavan (1) and (+/-)-7,4'-dihydroxy-3'-methoxyflavan (2), along with the synthesis of (+/-)-7,4'-dihydroxyflavan (3), three naturally occurring flavans, were described. The key step is the cyclization of 1,3-diaryl-1-propanol by (BF3Et2O)-Et-..

  DOI：

  10.1081/scc-120024733

文献信息

• Studies on Flavans. III. The Total Synthesis of (±)-7,4′-Dihydroxy-3′-methoxyflavan, (±)-7,3′-Dihydroxy-4′-methoxyflavan, and (±)-7,4′-Dihydroxyflavan
  作者：Jijun Xue、Xianshu Zhang、Xuesong Chen、Yingpeng Zhang、Ying Li

  DOI：10.1081/scc-120024733

  日期：2003.10

  The first total synthesis of (+/-)-7,3'-dihydroxy-4'-methoxyflavan (1) and (+/-)-7,4'-dihydroxy-3'-methoxyflavan (2), along with the synthesis of (+/-)-7,4'-dihydroxyflavan (3), three naturally occurring flavans, were described. The key step is the cyclization of 1,3-diaryl-1-propanol by (BF3Et2O)-Et-..