4-methoxy-5-methyl-hexan-2-one | 52117-36-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-5-methyl-hexan-2-one
• 英文别名: 4-Methoxy-5-methylhexan-2-one
• CAS: 52117-36-9
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: XOIJLNVFXHCJES-UHFFFAOYSA-N

物化性质

• 沸点：
  183.3±13.0 °C(Predicted)
• 密度：
  0.874±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酸异丙烯酯 、 1,1-二甲氧基-2-甲基丙烷 在 四氯化钛 作用下， 以 二氯甲烷 为溶剂， 生成 4-methoxy-5-methyl-hexan-2-one
  参考文献：
  名称：

  在路易斯酸的存在下，烯醇乙酸酯与缩醛和羰基化合物的反应

  摘要：

  发现在路易斯酸如 TiCl4、AlCl3、SnCl4、ZnCl2 和 BF3·O(C2H5)2 的存在下，烯醇乙酸酯与各种缩醛和苯甲醛反应，以良好的收率得到相应的醇醛型加成产物.

  DOI：

  10.1246/cl.1974.323

文献信息

• <scp>l</scp>-Proline-Catalyzed One-Pot Three-Component Reaction for the Synthesis of β-Alkoxy Ketones
  作者：Cong-Gui Zhao、Rajasekhar Dodda

  DOI：10.1055/s-2006-950184

  日期：——

  reaction of aliphatic aldehydes, ketones, and alcohols catalyzed by L-proline. Steric effects on the reaction were studied with substituted ketones, aldehydes, and alcohols, and the results indicate that reactions employing methyl ketones, α-unsubstituted aliphatic aldehydes and methanol produce the β-alkoxy ketones in the best yields when L-proline is used as the catalyst. The reaction mechanism is discussed

  L-脯氨酸催化脂肪醛、酮和醇的一锅三组分反应制备β-烷氧基酮。研究了取代酮、醛和醇对反应的空间位阻效应，结果表明，使用甲基酮、α-未取代脂肪醛和甲醇的反应以 L-脯氨酸为原料时生成 β-烷氧基酮的产率最高。催化剂。讨论了反应机理。
• POLYHYDROXYALKANOIC ACID COPOLYMER AND PROCESS FOR PREPARING SAME
  申请人：Tsuge Takeharu

  公开号：US20110081692A1

  公开（公告）日：2011-04-07

  A PHA copolymer comprising (R)-3-hydroxy-4-methyl valeric acid units and a production method thereof are provided. A polyhydroxyalkanoic acid copolymer comprising at least (R)-3-hydroxy-4-methyl valeric acid units; and a method of producing a polyhydroxyalkanoic acid copolymer comprising at least (R)-3-hydroxy-4-methyl valeric acid units, wherein in the presence of a carbon source and a precursor of (R)-3-hydroxy-4-methyl valeric acid, a transformant in which the gene of polyhydroxyalkanoic acid-polymerizing enzyme has been introduced in a microorganism selected from Escherichia coli, Ralstoniau sp., and Pseudomonas sp. is cultured, and from the culture obtained a polyhydroxyalkanoic acid copolymer comprising at least (R)-3-hydroxy-4-methyl valeric acid units is collected.
• US8394613B2
  申请人：——

  公开号：US8394613B2

  公开（公告）日：2013-03-12
• REACTION OF ENOL ACETATE WITH ACETAL AND CARBONYL COMPOUND IN THE PRESENCE OF LEWIS ACID
  作者：Teruaki Mukaiyama、Toshio Izawa、Kazuhiko Saigo

  DOI：10.1246/cl.1974.323

  日期：1974.4.5

  It was found that, in the presence of Lewis acid such as TiCl4, AlCl3, SnCl4, ZnCl2, and BF3·O(C2H5)2, enol acetate reacts with various acetals and benzaldehyde to afford the corresponding aldol-type addition products in good yields.

  发现在路易斯酸如 TiCl4、AlCl3、SnCl4、ZnCl2 和 BF3·O(C2H5)2 的存在下，烯醇乙酸酯与各种缩醛和苯甲醛反应，以良好的收率得到相应的醇醛型加成产物.