2-羟基-1-十九烷醇 | 39516-65-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2-羟基-1-十九烷醇
• 英文名称: 2-hydroxy-1-nonadecanol
• 英文别名: 1,2-nonadecanediol；1,2-Nonadecandiol；1,2-Dihydroxynonadecan；Nonadecandiol-(1,2)；1,2-dihydroxynonadecane；nonadecane-1,2-diol；Nonadecan-1,2-diol
• CAS: 39516-65-9
• 化学式: C₁₉H₄₀O₂
• 分子量: 300.525
• InChiKey: OFLPOBPCVHNRMF-UHFFFAOYSA-N

物化性质

• 熔点：
  55°C (estimate)
• 沸点：
  329.9°C (rough estimate)
• 密度：
  0.8675 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  21
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-羟基-1-十九烷醇 在 lead(IV) acetate 、 溶剂黄146 、 苯 作用下， 生成 硬脂烷醛
  参考文献：
  名称：

  Grundmann, Justus Liebigs Annalen der Chemie, 1936, vol. 524, p. 45

  摘要：

  DOI：
• 作为产物：
  描述：

  6b,7a-二氢苯并[1,10]醋菲烯并[4,5-b]噁丙烯 在 叔丁基过氧化氢 、 四氧化锇 作用下， 以 丙酮 、 叔丁醇 为溶剂， 以80%的产率得到2-羟基-1-十九烷醇
  参考文献：
  名称：

  双取代的四氢呋喃和二氧戊环以及PAF拮抗剂。

  摘要：

  制备了一系列新的双取代的四氢呋喃和二氧戊环衍生物，并在PAF诱导的体外血小板聚集和体内低血压试验中评估了它们的PAF拮抗剂活性。这些化合物中的几种显示出比与结构相关的2- [N-乙酰基-N-[[[[2-甲氧基-3-[（十八烷基氨基甲酰基）氧基]丙氧基]羰基]氨基]甲基] -1-乙基吡啶鎓氯化物更有效的活性。 （CV-6209，3）在体外试验中，而在体内试验中均显示出较低的效价。讨论了取代基性质以及环中氧原子的位置和数量的作用。对这些核进行了定量SAR研究。

  DOI：

  10.1021/jm00105a058

文献信息

• New 1,3-dioxolane-2-yl derivatives of 2-picolylamine
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0393512A1

  公开（公告）日：1990-10-24

  The present invention relates to new 1,3-dioxolan-2-yl derivatives of 2-picolylamine having the formula (I): wherein: R₁ represents an alkyl radical; R₂ represents hydrogen, or a C(=O)R₄ group, wherein R₄ represents C₁-C₆-alkyl or C₁-C₆-alxoxide; X is a single bond, or a -O-, -C(=O)O-, -OC(=O)C-, or -NR₅C(=O)O- group, wherein R₅ is H, C₁-C₄ alkyl or C₁-C₄ acyl; q is 0 or 1; t is (+) when q=1, and t has no meaning when q=0; R₃ is H or C₁-C₆ alkyl when q=1 and an electron pair when q=0; A⁻ is a pharmaceutically acceptable anion. The invention also relates to a procedure for their preparation and to pharmaceutical compositions containing them. These compounds are antagonists of PAF and, thus, useful for the treatment of the diseases in which this substance is involved.

  本发明涉及新的2-吡啶基氨基甲酸酯的1,3-二氧杂环己烷-2-基衍生物，其化学式为(I)：其中：R₁代表烷基基团；R₂代表氢或C（=O）R₄基团，其中R₄代表C₁-C₆烷基或C₁-C₆氧化物基；X是单键，或-O-，-C（=O）O-，-OC（=O）C-或-NR₅C（=O）O-基团，其中R₅为H，C₁-C₄烷基或C₁-C₄酰基；q为0或1；当q=1时，t为（+），当q=0时，t无意义；R₃为H或C₁-C₆烷基，当q=1时为电子对；A⁻为药学上可接受的阴离子。本发明还涉及它们的制备方法和含有它们的制药组合物。这些化合物是PAF拮抗剂，因此，对于涉及此物质的疾病的治疗是有用的。
• [EN] NATURAL OIL-DERIVED POLYESTER POLYOLS AND POLYURETHANES MADE THEREFROM<br/>[FR] POLYOLS DE POLYESTER DÉRIVÉS D'HUILE NATURELLE ET POLYURÉTHANES OBTENUS À PARTIR DE CEUX-CI
  申请人：CARGILL INC

  公开号：WO2009058367A1

  公开（公告）日：2009-05-07

  A polyester polyol made from natural oil feedstocks is disclosed. Methods for making the polyol are also disclosed. The method comprises reacting monohydroxylated fatty acid/alkyl esters with a multifunctional ester-reactive initiator compound to form the polyester polyol. In one embodiment, the monohydroxylated fatty acid/alkyl esters are made by hydroxylating fatty acid/alkyl esters having greater than about ninety-five percent by weight monounsaturation.

  本发明揭示了一种由天然油类原料制成的聚酯多元醇。本发明还揭示了制备聚酯多元醇的方法。该方法包括将单羟基脂肪酸/烷基酯与多功能酯反应性引发剂化合物反应以形成聚酯多元醇。在一种实施例中，所述的单羟基脂肪酸/烷基酯是通过对具有大于约95重量％单不饱和度的脂肪酸/烷基酯进行羟基化而制得的。
• Chemical product, process for the preparation and coating compositions thereof and articles coated therewith
  申请人：HENKEL CORPORATION (a Delaware corp.)

  公开号：EP0026984A1

  公开（公告）日：1981-04-15

  The invention relates to a chemical product produced by reacting a methylolamino compound and at least one polyhydric alcohol of functional derivative thereof; the said alcohol being selected from diols of formula I (wherein h and k, which may be the same or different, are integers the sum of which is from 12 to 20; k is greater than or equal to 3; and h is greater than or equal to 1) and gem-bis(hydroxymethyl) alcohols of formula II wherein m, n, p, q, r, s and t are integers the sum of which is from 12 to 20; n, q, and s each has a value of 0 or 1 with the sum of n, q and s having a value of from 1 to 3; m, p and r, which may be the same or different, each has a value of from 0 to 16; and t has a value of from 3 to 19. The invention further relates to a process for preparing the chemical product of the invention and compositions thereof. The chemical product of the invention is of particular use in the preparation of coating compositions.

  本发明涉及一种通过甲基氨基化合物和至少一种其官能衍生物的多元醇反应生成的化学产品；所述醇选自式 I 的二元醇 (其中 h 和 k 可以相同或不同，均为其总和为 12 至 20 的整数；k 大于或等于 3；h 大于或等于 1）和式 II 的 gem-双（羟甲基）醇 其中 m、n、p、q、r、s 和 t 为整数，其和为 12 至 20；n、q 和 s 的值均为 0 或 1，n、q 和 s 的值之和为 1 至 3；m、p 和 r 可以相同或不同，其值均为 0 至 16；t 的值为 3 至 19。 本发明还涉及一种制备本发明化学产品及其组合物的工艺。 本发明的化学产品特别适用于制备涂料组合物。
• Isocyanate-terminated prepolymers with low free monomer contents
  申请人：MOBAY CORPORATION

  公开号：EP0107014A1

  公开（公告）日：1984-05-02

  The present invention is directed to a process for the preparation of an isocyanate-terminated prepolymer having a content of unreacted diisocyanate of less than about 2% by weight, preferably less than about 1% by weight, based on the weight of the isocyanate-terminated prepolymer, and containing internal urethane groups based on 4,4'-diisocyanato-dicyclohexyl-methane by a) preparing an OH-terminated prepolymer from i) a high molecular weight polyol component, and/or ii) a low molecular weight isocyanate-reactive component, and iii) a polyisocyanate component comprising 4,4'-diisocyanato-dicyclohexyl methane at an NCO/OH equivalent ratio of about 0.5:1 to 0.9:1; b) forming the isocyanate-terminated prepolymer by reacting the OH-terminated prepolymer with a polyisocyanate other than 4,4'-diisocyanato-dicyclohexyl-methane containing aromatically-, aliphatically- and/or cycloaliphatically-bound isocyanate groups at an NCO:OH equivalent ratio, based on the free -OH groups of component (a), of about 1.6:1 to 15:1, and c) reducing the amount of unreacted diisocyanate to less than about 2% by weight, based on the weight of the isocyanate-terminated prepolymer. The present invention is also directed to the products prepared by this process and their use in one-component, moisture-cure systems or as the isocyanate component in two-component polyurethanes.

  本发明涉及一种异氰酸酯封端预聚物的制备工艺，该预聚物中未反应的二异氰酸酯含量小于约 2%（按重量计），最好小于约 1%（按重量计），并含有基于 4,4'-二异氰酸酯-二环己基甲烷的内聚氨酯基团。 a) 从以下物质中制备羟基封端预聚物 i) 高分子量多元醇组分，和/或 ii) 低分子量异氰酸酯反应组分，和 iii) 包含 4,4'-二异氰酸酯-二环己基甲烷的多异氰酸酯组分 NCO/OH 当量比约为 0.5:1 至 0.9:1； b) 通过使羟基封端预聚物与含有芳香族、脂族和/或环脂族结合异氰酸酯基团的 4,4'-二异氰酸酯-二环己基甲烷以外的多异氰酸酯反应，形成异氰酸酯封端预聚物，其 NCO:OH 当量比（基于组分(a)的游离-OH 基团）约为 1.6:1 至 15:1，以及 c) 以异氰酸酯封端预聚物的重量为基准，将未反应的二异氰酸酯的量减少至小于约 2% （按重量计）。 本发明还涉及由该工艺制备的产品及其在单组分湿气固化体系中或作为双组分聚氨酯中异氰酸酯组分的用途。
• Hydroxymethyl polyols
  申请人：HENKEL CORPORATION (a Delaware corp.)

  公开号：EP0106491A2

  公开（公告）日：1984-04-25

  Non-gelling polyols and alkoxylated polyol derivatives, particularly useful in the manufacture of polyurethanes, are disclosed. The polyols of formula I (wherein R represents a polyol, polyamine or aminoalcohol residue; p is an integer of from 2 to 6; each X, which may be the same or different, represents an oxygen or nitrogen atom or a group > NH; each a, which may be the same or different, is an integer of from 0 to 10, the sum of all a's being greater than 0; and each A, which may the same or different, represents a group of formula A,, A3 [wherein m and n are integers; m is greater than 3; n is greater than or equal to 0; and the sum of m and n is from 11 to 19] or A2 [wherein q, r and s are integers; q is greater than 3; r and s, which may be the same or different, are each greater than or equal to 0; and the sum of q, r and s is from 10 to 18]; with the proviso that where each X represents an oxygen atom, p is 3, each A is A, and each a is 1, then R represents other than the residue of glycerol) are prepared by reacting a hydroxymethyl containing monomer compound with a polyol, polyamine or aminoalcohol.

  本发明公开了特别适用于制造聚氨酯的非胶凝型多元醇和烷氧基化多元醇衍生物。式 I 的多元醇 (其中 R 代表多元醇、多胺或氨基醇残基；p 是 2 至 6 的整数；每个 X（可以相同或不同）代表氧原子或氮原子或基团 >NH；每个 a（可以相同或不同）是 0 至 10 的整数，所有 a 的总和大于 0；每个 A（可以相同或不同）代表式 A、A3 的基团 [其中 m 和 n 为整数；m 大于 3；n 大于或等于 0；m 和 n 之和为 11 至 19]或 A2 [其中 q、r 和 s 为整数；q 大于 3；r 和 s（可以相同或不同）各自大于或等于 0；且 q、r 和 s 之和为 10 至 18]；但其中每个 X 代表一个氧原子，p 为 3，每个 A 为 A，且每个 a 为 1，则 R 代表甘油残基以外的其他物质）是通过将含羟甲基的单体化合物与多元醇、多胺或氨基醇反应制备的。

表征谱图