1-(2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl))-5-(dimethoxymethyl)-6-(3-hydroxypropyl)uridine | 149204-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-(2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl))-5-(dimethoxymethyl)-6-(3-hydroxypropyl)uridine
• CAS: 149204-10-4
• 化学式: C₂₄H₄₂N₂O₉Si
• 分子量: 530.691
• InChiKey: LHYZEXSPDFAFKU-DLVXIWMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.19
• 重原子数：
  36.0
• 可旋转键数：
  10.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  130.47
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  1-(2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl))-5-(dimethoxymethyl)-6-(3-hydroxypropyl)uridine 在 三丁基膦 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 1-(2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl))-5-(dimethoxymethyl)-6-allyluridine
  参考文献：
  名称：

  A chemical model for the fragmentation reaction in thymidylate synthase catalysis. Synthesis and evaluation of a 5-methylene-1-(1,2,3,4-tetrahydroquinolyl)-6-allyluridine

  摘要：

  Compounds 5 and 6 were synthesized as models to investigate the reactivity of proposed intermediate 2 in thymidylate synthase (TS) catalysis as it fragments to form dTMP. The mechanism of the fragmentation (homolytic or heterolytic) of model 6 was determined via subsequent interaction of the fragmented center with the C6 allyl substituent. The results were consistent with an ionic fragmentation of 6, followed by loss of an allylic proton, and subsequent thermal electrocyclic or Diels-Alder reactions of the resulting trienes 13 and 14, respectively. Independent generation of radicals analogous to that produced from a radical fragmentation of model 6 did not result in formation of trienes 13 and 14.

  DOI：

  10.1021/jo00062a014
• 作为产物：
  描述：

  2’,3’邻异亚丙基尿苷 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 氯化铵 、 对甲苯磺酸 、 三乙胺 、 三氟乙酸 、 lithium diisopropyl amide 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 92.0h， 生成 1-(2',3'-O-isopropylidene-5'-O-(tert-butyldimethylsilyl))-5-(dimethoxymethyl)-6-(3-hydroxypropyl)uridine
  参考文献：
  名称：

  A chemical model for the fragmentation reaction in thymidylate synthase catalysis. Synthesis and evaluation of a 5-methylene-1-(1,2,3,4-tetrahydroquinolyl)-6-allyluridine

  摘要：

  Compounds 5 and 6 were synthesized as models to investigate the reactivity of proposed intermediate 2 in thymidylate synthase (TS) catalysis as it fragments to form dTMP. The mechanism of the fragmentation (homolytic or heterolytic) of model 6 was determined via subsequent interaction of the fragmented center with the C6 allyl substituent. The results were consistent with an ionic fragmentation of 6, followed by loss of an allylic proton, and subsequent thermal electrocyclic or Diels-Alder reactions of the resulting trienes 13 and 14, respectively. Independent generation of radicals analogous to that produced from a radical fragmentation of model 6 did not result in formation of trienes 13 and 14.

  DOI：

  10.1021/jo00062a014