3-(tert-butylperoxy)-3-(tert-butylperoxymethyl)-oxindole | 1246745-01-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(tert-butylperoxy)-3-(tert-butylperoxymethyl)-oxindole
• 英文别名: 3-tert-butylperoxy-3-(tert-butylperoxymethyl)-1H-indol-2-one
• CAS: 1246745-01-6
• 化学式: C₁₇H₂₅NO₅
• 分子量: 323.389
• InChiKey: RCYDCDJTMZKBQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(tert-butylperoxy)-3-(tert-butylperoxymethyl)-oxindole 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 10.0h， 以90%的产率得到3-hydroxy-3-(hydroxymethyl)indolin-2-one
  参考文献：
  名称：

  Palladium-Catalyzed Tandem Diperoxidation/C−H Activation Resulting in Diperoxy-oxindole in Air

  摘要：

  A highly efficient and facile palladium-catalyzed tandem diperoxidation and C-H activation process was reported, which provides a new pathway for the synthesis of biologically active diperoxides as well as oxindole derivatives from readily available starting materials in excellent chemical yields

  DOI：

  10.1021/ol101664y
• 作为产物：
  描述：

  叔丁基过氧化氢 、 N-苯基丙烯酰胺 在 palladium diacetate 、 溶剂黄146 作用下， 反应 6.0h， 以70%的产率得到3-(tert-butylperoxy)-3-(tert-butylperoxymethyl)-oxindole
  参考文献：
  名称：

  Palladium-Catalyzed Tandem Diperoxidation/C−H Activation Resulting in Diperoxy-oxindole in Air

  摘要：

  A highly efficient and facile palladium-catalyzed tandem diperoxidation and C-H activation process was reported, which provides a new pathway for the synthesis of biologically active diperoxides as well as oxindole derivatives from readily available starting materials in excellent chemical yields

  DOI：

  10.1021/ol101664y

文献信息

• Palladium-Catalyzed Tandem Diperoxidation/C−H Activation Resulting in Diperoxy-oxindole in Air
  作者：Guanghui An、Wei Zhou、Guangqian Zhang、Hao Sun、Jianlin Han、Yi Pan

  DOI：10.1021/ol101664y

  日期：2010.10.15

  A highly efficient and facile palladium-catalyzed tandem diperoxidation and C-H activation process was reported, which provides a new pathway for the synthesis of biologically active diperoxides as well as oxindole derivatives from readily available starting materials in excellent chemical yields