3-chloro-2-(chloromethyl)-1,2-propanediol | 23787-74-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-chloro-2-(chloromethyl)-1,2-propanediol
• 英文别名: 3-chloro-2-chloromethyl-propane-1,2-diol；3-Chlor-2-chlormethyl-propan-1,2-diol；3-Chloro-2-(chloromethyl)propane-1,2-diol
• CAS: 23787-74-8
• 化学式: C₄H₈Cl₂O₂
• mdl: MFCD19232606
• 分子量: 159.012
• InChiKey: BCKLGTUOKJTIQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-chloro-2-(chloromethyl)-1,2-propanediol 在 sodium hydroxide 作用下， 生成 2-chloromethyl-2-hydroxymethyl-oxirane
  参考文献：
  名称：

  Hearne; de Jong, Industrial and Engineering Chemistry, 1941, vol. 33, p. 941

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 磷酸 作用下， 生成 3-chloro-2-(chloromethyl)-1,2-propanediol
  参考文献：
  名称：

  Treatment of halogenated epoxides

  摘要：

  公开号：

  US02086077A1

文献信息

• A new family of water-soluble, third-generation antitumor platinum complexes
  作者：Panayota Bitha、Suzanne G. Carvajal、Ronald V. Citarella、Eugenia F. Delos Santos、Fredrick E. Durr、Joseph J. Hlavka、S. A. Lang、Harry L. Lindsay、John P. Thomas

  DOI：10.1021/jm00129a008

  日期：1989.9

  [1,1-Cyclobutanedicarboxylato(2)-O,O'](1,3-dioxane-5,5-dimethan amine- N,N')platinum(II), 3a, a third generation, very water-soluble platinum complex, has been synthesized along with several of its analogues. All members of the new family contain a 1,3-dioxane or 1,3-dioxolane-1,3-diamine as their basic ligand, a moiety which contributes to their increased water solubility, and a bidentate acid ligand, which is responsible for their good stability. They were all easily crystallized and characterized by 1H NMR and elemental analysis, and the parent complex 3a was further characterized by 13C NMR. Their very desirable physical properties combined with their broad spectrum of antitumor activity and reduced toxicity make them good candidates of further development.
• Treatment of halogenated epoxides
  申请人：SHELL DEV

  公开号：US02086077A1

  公开（公告）日：1937-07-06
• Treatment of halogenated polyhydric alcohols
  申请人：SHELL DEV

  公开号：US02070990A1

  公开（公告）日：1937-02-16
• BITHA, PANAYOTA;CARVAJAL, SUZANNE G.;CITARELLA, RONALD V.;SANTOS, EUGENIA+, J. MED. CHEM., 32,(1989) N, C. 2063-2067
  作者：BITHA, PANAYOTA、CARVAJAL, SUZANNE G.、CITARELLA, RONALD V.、SANTOS, EUGENIA+

  DOI：——

  日期：——
• 1,3-Bisarylglycerinäther und deren Verwendung
  申请人：BASF Aktiengesellschaft

  公开号：EP0009126B1

  公开（公告）日：1981-05-13