6-O-methyl-9-deoxo-8a-aza-8a-homoerythromycin A | 348125-80-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-O-methyl-9-deoxo-8a-aza-8a-homoerythromycin A
• 英文别名: (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-10-methoxy-3,5,8,10,12,14-hexamethyl-1-oxa-7-azacyclopentadecan-15-one
• CAS: 348125-80-4
• 化学式: C₃₈H₇₂N₂O₁₂
• 分子量: 748.996
• InChiKey: VFIVLGGMNXVPOF-CFLXSVEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  52
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  178
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  6-O-methyl-9-deoxo-8a-aza-8a-homoerythromycin A 在 甲醇 、 甲酸 、 碘 、 sodium acetate 作用下， 以 氯仿 为溶剂， 反应 0.5h， 生成 3'-N-demethyl-6-O-methyl-9-deoxo-8a-aza-8a-homoerythromycin A
  参考文献：
  名称：

  [EN] 2'-O,3'-N-BRIDGED MACROLIDES
  [FR] MACROLIDES 2'-O,3'-N-PONTÉS

  摘要：

  ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.

  公开号：

  WO2009130189A1
• 作为产物：
  描述：

  6-O-methyl Ery A 9(Z)-oxime 在 吡啶 、 sodium tetrahydroborate 、 乙二醇 、 对甲苯磺酰氯 作用下， 以 乙醚 为溶剂， 生成 6-O-methyl-9-deoxo-8a-aza-8a-homoerythromycin A
  参考文献：
  名称：

  [EN] 2'-O,3'-N-BRIDGED MACROLIDES
  [FR] MACROLIDES 2'-O,3'-N-PONTÉS

  摘要：

  ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.

  公开号：

  WO2009130189A1

文献信息

• 2'-O,3'-N-BRIDGED MACROLIDES
  申请人：Bukvic-Krajacic Mirjana

  公开号：US20110039795A1

  公开（公告）日：2011-02-17

  Novel 2′-O,3′-N-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2′-O,3′-N-bridged 14-membered macrolides and to 2′-O,3′-N-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.
• [EN] 2'-O,3'-N-BRIDGED MACROLIDES<br/>[FR] MACROLIDES 2'-O,3'-N-PONTÉS
  申请人：GLAXOSMITHKLINE ZAGREB

  公开号：WO2009130189A1

  公开（公告）日：2009-10-29

  Novel 2 ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.

  ' -O, 3 ' -/V-bridged macrolides useful in treatment of inflammatory diseases. More particularly, the invention relates to 2 ' -O, 3 ' -/V-bridged 14- membered macrolides and to 2 ' - O, 3 ' -/V-bridged 15-membered azalide macrolides useful in treatment of neutrophil dominated inflammatory diseases resulting from neutrophilic infiltration and/or diseases associated with altered cellular functionality of neutrophils, to intermediates for their preparation, to the methods for their preparation, to their use as therapeutic agents, and to salts thereof.