activation of the primordial peptide cycle through the effect of microwave irradiation, giving a new variety of peptide derivatives: the α,α-ureidopeptides, as 1,3-disubstituted unsymmetrical ureas via hydantoin, starting from NCbz protected α,α-dipeptide methyl esters containing glycine as the C-terminal residue. The new ureidopeptide series were synthesized and structurally characterized by FT-IR, MS, 1H NMR
本文描述了通过微波辐射作用对原始肽循环进行合成有用的分解代谢途径激活,从而产生了一种新的肽衍
生物:α,α-
脲肽,作为通过乙内酰
脲的 1,3-二取代不对称
脲,从N Cbz开始含有甘
氨酸作为C端残基的受保护 α,α-二肽甲酯。合成了新的
脲基肽系列,并通过 FT-IR、MS、1 H NMR、13 C NMR 光谱和单晶 X 射线衍射分析进行了结构表征。Phe-Gly-
脲肽3h的分子结构和晶体堆积,命名为 C 12 H 14 N 2 O 5,处于单斜晶系和C2/c空间群,参数a = 32.42 Å,b = 9.62 Å,c = 8.40 Å,β =103.25°,且Z = 8,Z' =1,确认对新化合物评估的分配。该程序已扩展到 α,α-
脲肽中间体乙内酰
脲 Leu-Gly 4e , C 9 H 14 N 2 O 4的分离,证明了合成机理并在斜方晶系、Pbca空间群中结晶,参数如下a = 5