ethyl 7-bromo-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate | 194805-06-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: ethyl 7-bromo-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate
• 英文别名: ethyl 7-bromo-1-cyclopropyl-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate；ethyl 7-bromo-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylate
• CAS: 194805-06-6
• 化学式: C₁₆H₁₆BrNO₄
• 分子量: 366.211
• InChiKey: GXFKEMWNOIQDJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  ethyl 7-bromo-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate 在 bis-triphenylphosphine-palladium(II) chloride 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 xylene 为溶剂， 反应 9.0h， 生成 7-[2-(Benzyloxycarbonyl)isoindolin-5-yl]-1-cyclopropyl-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Hayashi, Kazuya; Takahata, Masahiro; Kawamura, Yasuhito, Arzneimittel-Forschung/Drug Research, 2002, vol. 52, # 12, p. 903 - 913

  摘要：

  DOI：

文献信息

• Quinoline and naphthyridine carboxylic acid antibacterials
  申请人：——

  公开号：US20020049223A1

  公开（公告）日：2002-04-25

  Compounds having formula (I) 1 or pharmaceutically acceptable salts or prodrugs thereof, are useful as antibacterial agents.

  具有化学式(I)1的化合物或其药用可接受的盐或前药，可用作抗菌剂。
• Quinolonecarboxylic acid derivatives or salts thereof
  申请人：Toyama Chemical Co., Ltd.

  公开号：US06025370A1

  公开（公告）日：2000-02-15

  The present invention relates to a quinolone-carboxylic acid derivative represented by the general formula [1], or its salt: ##STR1## Of the compounds of the present invention, preferable are compounds in which R.sup.2 represents a substituted or unsubstituted cycloalkyl group; R.sup.3 represents at least one member selected from the group consisting of a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl or lower alkoxy group, and a protected or unprotected hydroxyl or amino group; R.sup.4 represents a hydrogen atom or a substituted or unsubstituted lower alkyl group; each of R.sup.5 and R.sup.6 represents a hydrogen atom; and A represents C--Y in which Y represents a halogen atom, a lower alkyl or lower alkoxy group which may be substituted by one or more halogen atoms, or a protected or unprotected hydroxyl group.

  本发明涉及一种由一般式[1]表示的喹诺酮羧酸衍生物或其盐：##STR1## 本发明化合物中，R.sup.2代表取代或未取代的环烷基；R.sup.3代表氢原子，卤素原子，取代或未取代的低碳基或低碳氧基，以及受保护或未受保护的羟基或氨基中的至少一种成员；R.sup.4代表氢原子或取代或未取代的低碳基；R.sup.5和R.sup.6各自代表氢原子；A代表C-Y，其中Y代表卤素原子，可以被一个或多个卤素原子取代的低碳基或低碳氧基，或受保护或未受保护的羟基。
• QUINOLONECARBOXYLIC ACID DERIVATIVES OR SALTS THEREOF
  申请人：TOYAMA CHEMICAL CO., LTD.

  公开号：EP0882725A1

  公开（公告）日：1998-12-09

  Quinolonecaboxylic acid derivatives represented by general formula (I) or salts of these. Preferred are compounds wherein R2 represents optionally substituted cycloalkyl, R3 represents at least one member selected among hydrogen, halogeno, optionally substituted lower alkyl or alkoxy, and optionally protected hydroxy or amino, R4 represents hydrogen or optionally substituted lower alkyl, R5 and R6 each represents hydrogen, and A represents C-Y (where Y represents halogeno, lower alkyl or alkoxy each optionally substituted by halogeno, or optionally protected hydroxy).

  通式(I)代表的喹啉酮酸衍生物或其盐类。其中 R2 代表任选取代的环烷基，R3 代表选自氢、卤素、任选取代的低级烷基或烷氧基、任选保护的羟基或氨基中的至少一个成员，R4 代表氢或任选取代的低级烷基，R5 和 R6 各自代表氢，A 代表 C-Y（其中 Y 代表卤素、任选被卤素取代的低级烷基或烷氧基或任选保护的羟基）。
• QUINOLINE AND NAPHTHYRIDINE CARBOXYLIC ACID ANTIBACTERIALS
  申请人：ABBOTT LABORATORIES

  公开号：EP1226146A2

  公开（公告）日：2002-07-31
• US6025370A
  申请人：——

  公开号：US6025370A

  公开（公告）日：2000-02-15