1-prop-2-enyl-2-prop-2-ynoxy-9H-carbazole | 912548-67-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-prop-2-enyl-2-prop-2-ynoxy-9H-carbazole
• CAS: 912548-67-5
• 化学式: C₁₈H₁₅NO
• 分子量: 261.323
• InChiKey: OKPAUGXUNDWMPX-UHFFFAOYSA-N

物化性质

• 沸点：
  456.1±40.0 °C(predicted)
• 密度：
  1.181±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  25
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-prop-2-enyl-2-prop-2-ynoxy-9H-carbazole 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以67%的产率得到5-Ethenyl-7-oxa-18-azatetracyclo[9.7.0.02,8.012,17]octadeca-1(11),2(8),4,9,12,14,16-heptaene
  参考文献：
  名称：

  Synthesis of oxepine-, oxocine- and azepine-annulated carbazole derivatives by combined Claisen rearrangement and diene/enyne metathesis

  摘要：

  A new route to various medium ring heterocycle-annulated tetra-, penta- and hexacyclic carbazole derivatives has been developed using successive applications of three atom economic processes, viz. Claisen rearrangement, olefin metathesis and Diels-Alder reactions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.07.045
• 作为产物：
  描述：

  2-羟基咔唑 在 potassium carbonate 、 N,N-二乙基苯胺 作用下， 以 丙酮 为溶剂， 反应 27.0h， 生成 1-prop-2-enyl-2-prop-2-ynoxy-9H-carbazole
  参考文献：
  名称：

  Synthesis of oxepine-, oxocine- and azepine-annulated carbazole derivatives by combined Claisen rearrangement and diene/enyne metathesis

  摘要：

  A new route to various medium ring heterocycle-annulated tetra-, penta- and hexacyclic carbazole derivatives has been developed using successive applications of three atom economic processes, viz. Claisen rearrangement, olefin metathesis and Diels-Alder reactions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.07.045

文献信息

• Synthesis of oxepine-, oxocine- and azepine-annulated carbazole derivatives by combined Claisen rearrangement and diene/enyne metathesis
  作者：Shital K. Chattopadhyay、Shankar P. Roy、Debalina Ghosh、Gautam Biswas

  DOI：10.1016/j.tetlet.2006.07.045

  日期：2006.9

  A new route to various medium ring heterocycle-annulated tetra-, penta- and hexacyclic carbazole derivatives has been developed using successive applications of three atom economic processes, viz. Claisen rearrangement, olefin metathesis and Diels-Alder reactions. (c) 2006 Elsevier Ltd. All rights reserved.