((2S,3S,4S,5R,6R)-2-allyl-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-3-yloxy)(tert-butyl)dimethylsilane | 1015481-45-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((2S,3S,4S,5R,6R)-2-allyl-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-3-yloxy)(tert-butyl)dimethylsilane
• CAS: 1015481-45-4
• 化学式: C₃₆H₄₈O₅Si
• 分子量: 588.86
• InChiKey: BAYAKQMSVIZUPX-PEINCPOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.11
• 重原子数：
  42.0
• 可旋转键数：
  14.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.15
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  ((2S,3S,4S,5R,6R)-2-allyl-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-3-yloxy)(tert-butyl)dimethylsilane 在 dimethyl sulfide borane 、 双氧水 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Cytotoxic effects of C-glycosides in HOS and HeLa cell lines

  摘要：

  Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 mu M, the Gglucopyranoside 38 being the most active against HeLa (5.4 mu M) and the dichlorocyclopropyl derivative 42 against HOS (1.6 mu M). Some preliminary structure-activity relationships were established. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.060
• 作为产物：
  描述：

  (3R,4R,5S)-4,5-Bis-benzyloxy-3-benzyloxymethyl-2,7-dioxa-bicyclo[4.1.0]heptane 在 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成 ((2S,3S,4S,5R,6R)-2-allyl-4,5-bis(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-3-yloxy)(tert-butyl)dimethylsilane
  参考文献：
  名称：

  Cytotoxic effects of C-glycosides in HOS and HeLa cell lines

  摘要：

  Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 mu M, the Gglucopyranoside 38 being the most active against HeLa (5.4 mu M) and the dichlorocyclopropyl derivative 42 against HOS (1.6 mu M). Some preliminary structure-activity relationships were established. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.04.060

文献信息

• Satoh, Masanori; Mori, Masaki; Nakata, Tadashi, Heterocycles, 2007, vol. 74, # C, p. 259 - 263
  作者：Satoh, Masanori、Mori, Masaki、Nakata, Tadashi

  DOI：——

  日期：——
• Two-Directional Olefinic-Ester Ring-Closing Metathesis using Reduced Ti Alkylidenes. A Rapid Entry into Polycyclic Ether Skeletons
  作者：Yuan Zhang、Jon D. Rainier

  DOI：10.1021/ol8025439

  日期：2009.1.1

  The use of a reduced titanium ethylidene reagent In an efficient two-directional approach to polycyclic ether skeletons is described.