(+)-deoxyradicinin | 1360457-27-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+)-deoxyradicinin
• 英文别名: (+)-Deoxyradicinin；(2R)-2-methyl-7-[(E)-prop-1-enyl]-2,3-dihydropyrano[3,2-c]pyran-4,5-dione
• CAS: 1360457-27-7
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: SHGIAYIFKLLQOL-KGGZQZJCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-甲氧基-6-甲基-2H-吡喃酮 在 selenium(IV) oxide 、 sodium hexamethyldisilazane 、 四氯化钛 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.33h， 生成 (+)-deoxyradicinin
  参考文献：
  名称：

  Conversions of deoxyradicinin to radicinin and of radicinin to 3-epi-radicinin in the phytopathogenic fungus Bipolaris coicis

  摘要：

  Radicinin is a phytotoxic and antibiotic metabolite produced by some phytopathogenic fungi. Precursor administration and cell-free experiments with deoxyradicinin and radicinin were carried out in Bipolaris colds H13-3. When deoxyradicinin was administered to the fungus, radicinin and 3-epi-radicinin formed. When radicinin administered, 3-epi-radicinin was formed. Their formation was confirmed by cell-free experiments. Deoxyradicinin 3-monooxygenase which catalyzes conversion of deoxyradicinin to radicinin showed the best activity at 35 degrees C and pH 7.0, and required NAD(+) as co-enzyme. Its molecular weight was determined to be 130-184 kDa. Radicinin epimerase catalyzing the reaction of radicinin to 3-epi-radicinin was purified from a cell-free extract. Radicinin epimerase is a homodimer of a 28 kDa subunit, and its highest activity was achieved at 30-35 degrees C and pH 7.0-9.0. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.phytochem.2011.11.010

文献信息

• Conversions of deoxyradicinin to radicinin and of radicinin to 3-epi-radicinin in the phytopathogenic fungus Bipolaris coicis
  作者：Masanobu Suzuki、Emi Sakuno、Atsushi Ishihara、Jun-ichi Tamura、Hiromitsu Nakajima

  DOI：10.1016/j.phytochem.2011.11.010

  日期：2012.3

  Radicinin is a phytotoxic and antibiotic metabolite produced by some phytopathogenic fungi. Precursor administration and cell-free experiments with deoxyradicinin and radicinin were carried out in Bipolaris colds H13-3. When deoxyradicinin was administered to the fungus, radicinin and 3-epi-radicinin formed. When radicinin administered, 3-epi-radicinin was formed. Their formation was confirmed by cell-free experiments. Deoxyradicinin 3-monooxygenase which catalyzes conversion of deoxyradicinin to radicinin showed the best activity at 35 degrees C and pH 7.0, and required NAD(+) as co-enzyme. Its molecular weight was determined to be 130-184 kDa. Radicinin epimerase catalyzing the reaction of radicinin to 3-epi-radicinin was purified from a cell-free extract. Radicinin epimerase is a homodimer of a 28 kDa subunit, and its highest activity was achieved at 30-35 degrees C and pH 7.0-9.0. (C) 2011 Elsevier Ltd. All rights reserved.