2-Butyl-4-hydroxy-3-propan-2-yloxy-4-prop-1-en-2-ylcyclobut-2-en-1-one | 304467-83-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Butyl-4-hydroxy-3-propan-2-yloxy-4-prop-1-en-2-ylcyclobut-2-en-1-one
• 英文别名: 2-butyl-4-hydroxy-3-propan-2-yloxy-4-prop-1-en-2-ylcyclobut-2-en-1-one
• CAS: 304467-83-2
• 化学式: C₁₄H₂₂O₃
• 分子量: 238.327
• InChiKey: OKGJVYFYZGGPBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Butyl-4-hydroxy-3-propan-2-yloxy-4-prop-1-en-2-ylcyclobut-2-en-1-one 在 potassium carbonate 、 silver(l) oxide 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 3.0h， 生成 (2E,4E)-2-butyl-4-methoxy-5,8-dimethyl-3-propan-2-yloxycycloocta-2,4-dien-1-one
  参考文献：
  名称：

  Reaction of 4-methoxy-4-(1-methylethenyl)-2-cyclobutenone derivatives with 2-lithiopropene and α-lithiostyrene: synthesis of eight-membered ring carbocycles

  摘要：

  2-Alkyl- or phenyl-substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones react with 2-lithiopropene or alpha-lithiostyrene to produce 4-methoxy-2,4-cyclooctadienones in moderate yield, accompanied by varying amounts of 4-methoxy-4-(1-methylethenyl)-2-cyclohexenones. The reaction is general for 2-alkyl substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01173-4
• 作为产物：
  描述：

  isopropenyllithium 、 4-n-butyl-3-(1-methylethoxy)cyclobut-3-ene-1,2-dione 在 氯化铵 作用下， 以 四氢呋喃 为溶剂， 以84%的产率得到2-Butyl-4-hydroxy-3-propan-2-yloxy-4-prop-1-en-2-ylcyclobut-2-en-1-one
  参考文献：
  名称：

  Reaction of 4-methoxy-4-(1-methylethenyl)-2-cyclobutenone derivatives with 2-lithiopropene and α-lithiostyrene: synthesis of eight-membered ring carbocycles

  摘要：

  2-Alkyl- or phenyl-substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones react with 2-lithiopropene or alpha-lithiostyrene to produce 4-methoxy-2,4-cyclooctadienones in moderate yield, accompanied by varying amounts of 4-methoxy-4-(1-methylethenyl)-2-cyclohexenones. The reaction is general for 2-alkyl substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01173-4

文献信息

• Reaction of 4-methoxy-4-(1-methylethenyl)-2-cyclobutenone derivatives with 2-lithiopropene and α-lithiostyrene: synthesis of eight-membered ring carbocycles
  作者：Metin Zora、Ilkay Koyuncu、Baris Yucel

  DOI：10.1016/s0040-4039(00)01173-4

  日期：2000.9

  2-Alkyl- or phenyl-substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones react with 2-lithiopropene or alpha-lithiostyrene to produce 4-methoxy-2,4-cyclooctadienones in moderate yield, accompanied by varying amounts of 4-methoxy-4-(1-methylethenyl)-2-cyclohexenones. The reaction is general for 2-alkyl substituted 4-methoxy-4-(1-methylethenyl)-2-cyclobutenones. (C) 2000 Elsevier Science Ltd. All rights reserved.