3-(8-Chloro-3-formylimidazo[1,2-a]pyridin-2-yl)benzonitrile | 481049-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(8-Chloro-3-formylimidazo[1,2-a]pyridin-2-yl)benzonitrile
• 英文别名: 3-(8-chloro-3-formylimidazo[1,2-a]pyridin-2-yl)benzonitrile
• CAS: 481049-58-5
• 化学式: C₁₅H₈ClN₃O
• 分子量: 281.701
• InChiKey: PDTVWHYSUHZCGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(8-Chloro-3-formylimidazo[1,2-a]pyridin-2-yl)benzonitrile 在 manganese(IV) oxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 3-(8-Chloro-3-prop-2-ynoylimidazo[1,2-a]pyridin-2-yl)benzonitrile
  参考文献：
  名称：

  Imidazo[1,2-a]pyridines with potent activity against herpesviruses

  摘要：

  Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.079
• 作为产物：
  描述：

  3-氯-2-氨基吡啶 在 碳酸氢钠 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 生成 3-(8-Chloro-3-formylimidazo[1,2-a]pyridin-2-yl)benzonitrile
  参考文献：
  名称：

  Imidazo[1,2-a]pyridines with potent activity against herpesviruses

  摘要：

  Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.079

文献信息

• [EN] USE OF DERIVATIVES OF 2, 4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONE AS INHIBITORS O FTEH ENZYME MYELOPEROXIDASE (MPO)<br/>[FR] UTILISATION DE DERIVES DE 2, 4-DIHYDRO-[1,2,4]TRIAZOLE-3-THIONES COMME INHIBITEURS DE L'ENZYME MYELOPEROXYDASE (MPO)
  申请人：ASTRAZENECA AB

  公开号：WO2004096781A1

  公开（公告）日：2004-11-11

  There is disclosed the use of a compound of formula (I) wherein X, Y, W and Q are as defined in the specification, and pharmaceutically acceptable salts thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of the enzyme myeloperoxidase (MPO) is beneficial. Certain novel compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, together with processes for their preparation. The compounds of formulae (I) are MPO inhibitors and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders.

  揭示了使用公式(I)中X、Y、W和Q如规范中定义的化合物及其药用盐，在制造药物中用于治疗或预防对髓过氧化物酶（MPO）抑制有益的疾病或症状。公开了某些公式(I)的新化合物及其药用盐，以及它们的制备方法。公式(I)的化合物是MPO抑制剂，因此在治疗或预防神经炎症性疾病中特别有用。
• Imidazo[1,2-a]pyridine derivatives for treatment of herpes viral infections
  申请人：Gudmundsson Kristjan

  公开号：US20060167252A1

  公开（公告）日：2006-07-27

  The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物，其中所有变量在此定义，包含它们的药物组成物，制备它们的方法以及它们作为药物代理的用途。
• Imidazo'1,2-a!pyridine derivatives for the prophylaxis and treatment of herpes viral infections
  申请人：Gudmundsson S Kristjan

  公开号：US20050228004A1

  公开（公告）日：2005-10-13

  The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：其中所有变量如本文所定义，包含这些化合物的制药组合物，制备这些化合物的过程以及它们作为制药剂的用途。
• IMIDAZO¬1,2-A|PYRIDINE DERIVATIVES FOR THE PROPHYLAXIS AND TREATMENT OF HERPES VIRAL INFECTIONS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1401836B1

  公开（公告）日：2006-08-23
• USE OF DERIVATIVES OF 2, 4-DIHYDRO- 1,2,4 TRIAZOLE-3-THIONE AS INHIBITORS OF THE ENZYME MYELOPEROXIDASE (MPO)
  申请人：AstraZeneca AB

  公开号：EP1620410A1

  公开（公告）日：2006-02-01