[(2R,3R,4S,5R,6R)-5-benzoyloxy-6-dec-9-enoxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] benzoate | 280742-37-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [(2R,3R,4S,5R,6R)-5-benzoyloxy-6-dec-9-enoxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] benzoate
• CAS: 280742-37-2
• 化学式: C₃₀H₃₈O₈
• 分子量: 526.627
• InChiKey: NFNWJRHKVFZOIQ-RQHKYSNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  [(2R,3R,4S,5R,6R)-5-benzoyloxy-6-dec-9-enoxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] benzoate 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 吡啶 为溶剂， 生成 4-[(2R,3S,4S,5R,6R)-3,5-dibenzoyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-dec-9-enoxyoxan-4-yl]oxy-4-oxobutanoic acid
  参考文献：
  名称：

  Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan

  摘要：

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00153-2
• 作为产物：
  描述：

  [(2R,3S,4S,5R,6R)-3,4,5-triacetyloxy-6-dec-9-enoxyoxan-2-yl]methyl acetate 在 吡啶 、 4-二甲氨基吡啶 、 sodium methylate 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 吡啶 、 甲醇 、 乙腈 为溶剂， 生成 [(2R,3R,4S,5R,6R)-5-benzoyloxy-6-dec-9-enoxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl] benzoate
  参考文献：
  名称：

  Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan

  摘要：

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00153-2

文献信息

• Parasite glycoconjugates. Part 16: Synthesis of a disaccharide and phosphorylated di- and tri-saccharides from Leishmania lipophosphoglycan
  作者：Andrew J. Ross、Olga V. Sizova、Andrei V. Nikolaev

  DOI：10.1016/j.carres.2006.03.026

  日期：2006.8

  A neutral disaccharide beta-D-Ga1p-(1 -> 4)-alpha-D-Manp and phosphorylated di- and tri-saccharides beta-D-Galp-(1 -> 3)-[H(2)PO(3-)6]-beta-D-Ga1p-O[CH2](8)CH=CH2 and beta-D-Ga1p-(1 -> 3)-[H(2)PO(3-)6]-beta-D-Ga1p-(1 -> 4)-alpha-D-Manp, which are fragments of the phosphoglycan portion of the surface lipophosphoglycan from Leishmania donovani (the disaccharide) or Leishmania major (all three compounds), were prepared and used as TLC standards to help the identification and differentiation of the elongating and branching P-D-galactosyl transferase activities in Leishmania. The phosphosaccharides were synthesised using the H-phosphonate method for phosphorylation. (c) 2006 Elsevier Ltd. All rights reserved.
• Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan
  作者：Andrew J Ross、Irina A Ivanova、Adrian P Higson、Andrei V Nikolaev

  DOI：10.1016/s0040-4039(00)00153-2

  日期：2000.4

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.