4-[(2R,3S,4S,5R,6R)-3,5-dibenzoyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-dec-9-enoxyoxan-4-yl]oxy-4-oxobutanoic acid | 280742-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 4-[(2R,3S,4S,5R,6R)-3,5-dibenzoyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-dec-9-enoxyoxan-4-yl]oxy-4-oxobutanoic acid
• CAS: 280742-39-4
• 化学式: C₅₅H₆₀O₁₃
• 分子量: 929.074
• InChiKey: HIARILKWERPLRC-YRBOJYMCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11
• 重原子数：
  68
• 可旋转键数：
  29
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  162
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  triethylammonium 2,3,4,6-tetra-O-benzoyl-α-D-mannopyranosyl hydrogenphosphonate 、 triethylammonium 2,3,6-tri-O-benzoyl-4-O-[2,3,4-tri-O-benzoyl-6-O-(p,p'-dimethoxytrityl)-β-D-galactopyranosyl]-α-D-mannopyranosyl hydrogenphosphonate 、 4-[(2R,3S,4S,5R,6R)-3,5-dibenzoyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-dec-9-enoxyoxan-4-yl]oxy-4-oxobutanoic acid 以40%的产率得到α-D-Manp-(1-PO3H-6)-β-D-Galp-(1->4)-α-D-Manp-(1-PO3H-6)-β-D-Galp-O[CH2]8CH:CH2
  参考文献：
  名称：

  Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan

  摘要：

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00153-2
• 作为产物：
  描述：

  9-decenyl β-D-galactopyranoside 在 吡啶 、 4-二甲氨基吡啶 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 吡啶 、 乙腈 为溶剂， 生成 4-[(2R,3S,4S,5R,6R)-3,5-dibenzoyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-6-dec-9-enoxyoxan-4-yl]oxy-4-oxobutanoic acid
  参考文献：
  名称：

  Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan

  摘要：

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00153-2

文献信息

• Application of MPEG soluble polymer support in the synthesis of oligo-phosphosaccharide fragments from the Leishmania lipophosphoglycan
  作者：Andrew J Ross、Irina A Ivanova、Adrian P Higson、Andrei V Nikolaev

  DOI：10.1016/s0040-4039(00)00153-2

  日期：2000.4

  A polymer (MPEG) supported synthesis of the phosphorylated tetra- and hexa-saccharide fragments of the lipophosphoglycan from Leishmania has been developed using mono- and di-saccharide H-phosphonates for construction of the phosphodiester bridges. (C) 2000 Elsevier Science Ltd. All rights reserved.