4-{[(8-hydroxyquinolin-5-yl)methyl]amino}benzenesulfonamide | 1259419-39-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-{[(8-hydroxyquinolin-5-yl)methyl]amino}benzenesulfonamide
• 英文别名: 4-[(8-Hydroxy-5-quinolyl)methylamino]benzenesulfonamide；4-[(8-hydroxyquinolin-5-yl)methylamino]benzenesulfonamide
• CAS: 1259419-39-0
• 化学式: C₁₆H₁₅N₃O₃S
• 分子量: 329.379
• InChiKey: VYVQKGPMDCVEEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-(氯甲基)-8-羟基喹啉盐酸盐 、 磺胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 生成 4-{[(8-hydroxyquinolin-5-yl)methyl]amino}benzenesulfonamide
  参考文献：
  名称：

  Vanparia, Satish F.; Patel, Tarosh S.; Sojitra, Natvar A., Acta Chimica Slovenica, 2010, vol. 57, # 3, p. 660 - 667

  摘要：

  DOI：

文献信息

• Parkin ligase activation methods and compositions
  申请人：An2H Discovery Limited

  公开号：US10155936B2

  公开（公告）日：2018-12-18

  The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase.

  本发明涉及通过向有需要的受试者施用治疗有效量的破坏至少一个Parkin连接酶锌指的化合物来激活Parkin连接酶的方法和组合物。本发明还涉及治疗和/或降低与激活Parkin连接酶有关的疾病或病症发病率的方法。
• PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS
  申请人：An2H Discovery Limited

  公开号：US20160160205A1

  公开（公告）日：2016-06-09

  The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase.
• Vanparia, Satish F.; Patel, Tarosh S.; Sojitra, Natvar A., Acta Chimica Slovenica, 2010, vol. 57, # 3, p. 660 - 667
  作者：Vanparia, Satish F.、Patel, Tarosh S.、Sojitra, Natvar A.、Jagani, Chandresh L.、Dixit, Bharat C.、Patel, Pradeep S.、Dixit, Ritu B.

  DOI：——

  日期：——