1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮 | 110187-11-6

• 物质功能分类: 天然产物 - 氧杂蒽酮
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮
• 英文名称: 1,5,8-trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)xanthene-9-one
• 英文别名: 1,5,8-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)xanthone；1,5,8-trihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthone；1,5,8-trihydroxy-3-methoxy-2[3-methyl-2-butenyl]xanthone；1,5,8-trihydroxy-3-methoxy-2-prenylxanthone；1,5,8-Trihydroxy-3-methoxy-2-(3-methylbut-2-en-1-yl)-9H-xanthen-9-one；1,5,8-trihydroxy-3-methoxy-2-(3-methylbut-2-enyl)xanthen-9-one
• CAS: 110187-11-6
• 化学式: C₁₉H₁₈O₆
• 分子量: 342.348
• InChiKey: AAANZTDKTFGJLZ-UHFFFAOYSA-N

物化性质

• 熔点：
  193-195 °C
• 沸点：
  591.8±50.0 °C(Predicted)
• 密度：
  1.376±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮 、 乙酸酐 生成 [4-acetyloxy-8-hydroxy-6-methoxy-7-(3-methylbut-2-enyl)-9-oxoxanthen-1-yl] acetate
  参考文献：
  名称：

  PARVEEN, MEHTAB;KHAN, NIZAM UD-DIN, PHYTOCHEMISTRY, 27,(1988) N 11, C. 3694-3696

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-dihydroxy-5,8-dimethoxyxanthone 在 吗啉 、 水 作用下， 反应 168.0h， 生成 1,5,8-三羟基-3-甲氧基-2-异戊烯基氧杂蒽酮
  参考文献：
  名称：

  1,3,5,8-四氧合氧杂蒽在热水溶液吗啉中的重排

  摘要：

  2-异戊烯基-1-羟基-3,5,8-三甲氧基黄酮的吗啉去甲基化反应可得到1,3,5,8-和1,3,7,8-四氧杂蒽酮的混合物。

  DOI：

  10.1016/s0040-4039(01)93954-1

文献信息

• Oral compositions containing extracts of garcinia mangostana l. and related methods
  申请人：Colgate-Palmolive Company

  公开号：EP2689805A1

  公开（公告）日：2014-01-29

  Described herein are compositions comprising a combination of extracts, and methods of preparing and using the same.

  本文描述了包含提取物组合的组合物，以及制备和使用组合物的方法。
• Dietary supplement derived from natural prodcuts by hot melt extrusion (HME) processing
  申请人：Estrada Ramirez Omar Augusto

  公开号：US10555986B2

  公开（公告）日：2020-02-11

  The invention provides a composition rich in flavonoids based on natural extracts, comprising a flavonoid extract dispersed by melt mixing or extrusion and encapsulated in a polymer matrix. The invention is also a novel dietary supplement with the naturally occurring ingredient (−)-epicatechin, cacao extracted, that could potentially prevent or reduce the risk of Atherosclerotic pathology. The use of (−)-epicatechin is promising as a therapeutic agent due to its potential antioxidant activity and its diverse biological properties. (−)-Epicatechins are chemically unstable and extensively degraded in fluids of near neutral or greater pH, such as intestinal juice and bile. Current technologies used for taste masking and modified release as spray drying, liposome entrapment, co-crystallization, freeze drying, among others, suffer from numerous shortcomings, including poor repeatability and limitations on target delivery.

  本发明提供了一种基于天然提取物的富含类黄酮的组合物，该组合物由通过熔融混合或挤压分散的类黄酮提取物组成，并封装在聚合物基质中。本发明也是一种新型膳食补充剂，含有天然成分(-)-表儿茶素（可可提取物），有可能预防或降低动脉粥样硬化病变的风险。由于(-)-表儿茶素具有潜在的抗氧化活性和多种生物特性，因此很有希望用作治疗剂。(-)-表儿茶素化学性质不稳定，在pH值接近中性或更高的液体（如肠液和胆汁）中广泛降解。目前用于掩味和改性释放的技术包括喷雾干燥、脂质体包埋、共结晶、冷冻干燥等，这些技术存在许多缺点，包括可重复性差和靶向递送受限。
• Chemosensory receptor ligand-based therapies
  申请人：Anji Pharma (US) LLC

  公开号：US10610500B2

  公开（公告）日：2020-04-07

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含化感受体配体（如苦味受体配体）的组合物来治疗与化感受体相关的病症（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了化学感觉受体配体组合物，包括苦味受体配体组合物，及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• Nutraceutical mangosteen composition
  申请人：DBC, LLC

  公开号：US20040146592A1

  公开（公告）日：2004-07-29

  Nutraceutical compositions derived from the fruit of the Garcinia mangostana L. or mangosteen plant are provided. The nutraceutical mangosteen compositions employ novel combinations of mangosteen fruit pulp and pericarp, and can be additionally complemented by selected juice concentrates to yield a composition for improving general health and wellness in humans.

  从芒果果实中提取的营养成分 山竹果 L. 或山竹果植物的果实提取的保健成分。山竹果营养保健品组合物采用了山竹果果肉和果皮的新颖组合，还可辅以精选的浓缩果汁，以获得改善人体总体健康和保健的组合物。
• Pharmaceutical and therapeutic compositions derived from Garcinia mangostana L plant
  申请人：Moffett Alex

  公开号：US20060105069A1

  公开（公告）日：2006-05-18

  The present invention relates to pharmaceutical, therapeutic, nutritional, cosmetic, and dermatological compositions derived from the preicarp (rind) of the Garcinia mangostana L plant and the novel extraction processes used to produce those compositions. Specifically, the present invention relates, in part, to an approximately 0.01% to about 80% mixture of a xanthone-rich mangosteen pericarp (rind) extract in novel combinations for pharmaceutical, cosmetic, therapeutic or dermatological compositions that yield surprising health benefits. Additionally, the present invention relates, in part, to novel extraction processes that result in the production of the novel compositions of the invention.

  本发明涉及药物、治疗、营养、化妆品和皮肤病组合物，这些组合物由芒果树的果皮提取。 果皮 L 植物的前果皮（果皮）中提取的药物、治疗、营养、美容和皮肤病组合物，以及用于生产这些组合物的新型提取工艺。具体而言，本发明部分涉及一种富含氧杂蒽酮的山竹果果皮提取物的约 0.01% 至约 80% 的混合物，该混合物以新颖的组合方式用于制药、美容、治疗或皮肤病组合物，可产生令人惊喜的健康益处。此外，本发明还部分涉及可生产本发明新型组合物的新型提取工艺。