14-chloro-tetradecan-1-ol | 73937-05-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 14-chloro-tetradecan-1-ol
• 英文别名: 14-Chlor-tetradecylalkohol；14-Chlor-tetradecan-1-ol；14-Chloro-1-tetradecanol；14-chlorotetradecan-1-ol
• CAS: 73937-05-0
• 化学式: C₁₄H₂₉ClO
• 分子量: 248.837
• InChiKey: AZWALNMPJIXDRE-UHFFFAOYSA-N

物化性质

• 熔点：
  37-38 °C
• 沸点：
  156-160 °C(Press: 4 Torr)
• 密度：
  0.926±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  14-chloro-tetradecan-1-ol 在 氯化亚砜 、 乙醇 、 苯 作用下， 生成 1-chloro-14-methylsulfanyl-tetradecane
  参考文献：
  名称：

  Familial Head and Neck Cancer: Molecular Analysis of a New Clinical Entity

  摘要：

  AbstractObjective The tumor suppressor gene p16 encodes a cyclin‐dependent kinase inhibitor that normally inhibits cell proliferation by causing a G1 cell cycle arrest. The p16 gene is frequently mutated in a variety of somatic tumors, as well as in familial melanoma and familial pancreatic carcinoma. We identified a family with a high incidence of head and neck squamous cell carcinoma (HNSCC) and melanoma. Molecular analyses of the p16 gene locus in blood and tumor DNA from this family was performed to determine whether an association between germline p16 gene mutation and HNSCC exists.Study Design Molecular pedigree analyses.Methods Exon 2 of p16 was polymerase chain reaction amplified from blood, tumor, or nontumor DNA isolated from affected and unaffected members, then directly sequenced and compared with consensus p16 sequence. Cell cycle position of cells expressing wild‐type or mutant p16 was determined by flow cytometry.Results Molecular analyses revealed a nonfunctional germline point mutation within exon 2 of the p16 gene that encodes a mutant p16 protein substituting proline at amino acid position 87 for the wild‐type arginine (p16R87P). Relative to wild‐type p16, p16R87P lost ability to cause a growth arrest following ectopic expression. The mutant (p16R87P) allele segregated with cancer predisposition in tested family members, and analyses of HNSCC tumor tissues demonstrated universal loss of wild‐type allele.Conclusions Significance of the mutant p16 (p16R87P) in HNSCC tumorigenesis is strongly suggested by its loss of cell cycle arrest activity and its retention in tumor tissue with simultaneous loss of the wild‐type allele. Further, the germline p16 mutation segregated with cancer predisposition within the family. In aggregate, these data suggest that there is a direct causal relationship between the germline p16 mutation in this family and HNSCC tumorigenesis. Based on our observations, the spectrum of familial cancers associated with p16 mutations should include a new clinical entity, familial HNSCC.

  DOI：

  10.1097/00005537-200209000-00010
• 作为产物：
  描述：

  1,14-十四烷二醇 在 盐酸 作用下， 生成 1,14-dichlorotetradecane 、 14-chloro-tetradecan-1-ol
  参考文献：
  名称：

  135.脂族二醇的衍生物。第四部分

  摘要：

  DOI：

  10.1039/jr9380001679

文献信息

• CONTACT-KILLING, QAC FUNCTIONALIZED THERMOPLASTIC POLYURETHANE FOR CATHETER APPLICATIONS
  申请人：THE UNIVERSITY OF AKRON

  公开号：US20190106525A1

  公开（公告）日：2019-04-11

  In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

  在各种实施方式中，本发明提供了一种功能化的热塑性聚氨酯（TPU），其中包含大量引入或表面接枝的季铵化合物（QAC），用于接触杀灭多种微生物，其中QAC位于TPU表面，以提供一种无菌表面材料，防止通常涉及设备相关感染（DAIs）的细菌繁殖。本发明的功能化TPU可以形成多种三维形状，例如导管、医疗管、喉部或气管支架、缝合线、假体、伤口敷料和/或医疗设备的涂层，并包含含有二醇单体或烯功能二醇单体的QAC残留物，这使得TPU可以用含有二硫键或自由巯基化合物的QAC进行功能化，以形成具有用于医疗设备的抗菌性能的季铵功能化热塑性聚氨酯化合物。
• CHEMISORPTIVE SUBSTANCE, ALIGNED LIQUID-CRYSTAL FILM AND LIQUID-CRYSTAL DISPLAY ELEMENT BOTH MADE BY USING THE SAME, AND PROCESSES FOR PRODUCING THESE
  申请人：MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.

  公开号：EP0962460A1

  公开（公告）日：1999-12-08

  The present invention provides a new chemical adsorbent which can form an extremely thin and transparent film in nanometer order which is fixed uniformly and firmly on a substrate, and give an alignment characteristic of high thermal stability to the thin film; as well as a liquid crystal alignment layer and a liquid crystal display device having a desirable alignment characteristic, a superior alignment control force over a liquid crystal molecule, and a superior thermal stability by using the above-mentioned chemical adsorbent. This purpose can be actualized by developing a new compound which is transparent and stable in a range of a visible ray (a wavelength from 400 nm to 700 nm), and has a photosensitivity in a range of an ultraviolet ray and a far-ultraviolet ray (a wavelength from 200 nm to 400 nm), and can form a thin film in a monolayer through a chemisorption on a substrate.

  本发明提供了一种新的化学吸附剂，它能形成纳米级的极薄而透明的薄膜，均匀而牢固地固定在基片上，并使薄膜具有高热稳定性的配向特性；还提供了一种液晶配向层和液晶显示装置，通过使用上述化学吸附剂，该装置具有理想的配向特性、对液晶分子的超强配向控制力和超强的热稳定性。为了实现这一目的，可以开发一种新的化合物，它在可见光（波长 400 纳米至 700 纳米）范围内具有透明性和稳定性，在紫外线和远紫外线（波长 200 纳米至 400 纳米）范围内具有光敏性，并能通过化学吸附在基底上形成单层薄膜。
• Contact-killing, QAC functionalized thermoplastic polyurethane for catheter applications
  申请人：THE UNIVERSITY OF AKRON

  公开号：US11155668B2

  公开（公告）日：2021-10-26

  In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

  在各种实施例中，本发明提供了一种功能化热塑性聚氨酯（TPU），其中含有用于接触杀灭各种微生物的批量掺入或表面接枝的季铵化合物（QAC），其中 QAC 位于 TPU 表面，以提供一种无菌表面材料，防止常见于设备相关感染（DAI）的细菌增殖。本发明的功能化热塑性聚氨酯可制成各种三维形状，如导管、医用管道、喉或气管支架、缝合线、假肢、伤口敷料和/或医疗器械涂层，并含有含 QAC 的二元醇单体或烯功能二元醇单体的残留物、这样，热塑性聚氨酯就可以与含有二硫化物或游离硫醇化合物的 QAC 进行官能化，形成具有抗菌特性的季铵官能化热塑性聚氨酯化合物，用于医疗器械。
• Chemical adsorbent and liquid crystal alignment layer utilizing the same and liquid crystal display device utilizing the same and methods of manufacturing them
  申请人：Matsushita Electric Industrial Co., Ltd.

  公开号：US20030104145A1

  公开（公告）日：2003-06-05

  The present invention provides a new chemical adsorbent which can form an extremely thin and transparent film in nanometer order which is fixed uniformly and firmly on a substrate, and give an alignment characteristic of high thermal stability to the thin film; as well as a liquid crystal alignment layer and a liquid crystal display device having a desirable alignment characteristic, a superior alignment control force over a liquid crystal molecule, and a superior thermal stability by using the above-mentioned chemical adsorbent. This purpose can be actualized by developing a new compound which is transparent and stable in a range of a visible ray (a wavelength from 400 nm to 700 nm), and has a photosensitivity in a range of an ultraviolet ray and a far-ultraviolet ray (a wavelength from 200 nm to 400 nm), and can form a thin film in a monolayer through a chemisorption on a substrate.

  本发明提供了一种新的化学吸附剂，它能形成纳米级的极薄而透明的薄膜，均匀而牢固地固定在基片上，并使薄膜具有高热稳定性的配向特性；还提供了一种液晶配向层和液晶显示装置，通过使用上述化学吸附剂，该装置具有理想的配向特性、对液晶分子的超强配向控制力和超强的热稳定性。为了实现这一目的，可以开发一种新的化合物，它在可见光（波长 400 纳米至 700 纳米）范围内具有透明性和稳定性，在紫外线和远紫外线（波长 200 纳米至 400 纳米）范围内具有光敏性，并能通过化学吸附在基底上形成单层薄膜。
• Hydroxyalkylcysteine derivative and expectorant containing the same
  申请人：SS PHARMACEUTICAL CO., LTD.

  公开号：EP0346882B1

  公开（公告）日：1993-09-29