6-甲基-环己-1,5-二烯羧酸 | 859820-82-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 6-甲基-环己-1,5-二烯羧酸
• 英文名称: 6-methyl-cyclohexa-1,5-dienecarboxylic acid
• 英文别名: 2-Methyl-Δ^2.6-dihydro-benzoesaeure；Δ^2.6-Dihydro-o-toluylsaeure；6-Methyl-cyclohexa-1,5-diencarbonsaeure；6-Methylcyclohexa-1,5-diene-1-carboxylic acid
• CAS: 859820-82-9
• 化学式: C₈H₁₀O₂
• 分子量: 138.166
• InChiKey: LWCWFCCMKBDOLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-甲基-环己-1,5-二烯羧酸 、 alkaline earth salt of/the/ methylsulfuric acid 生成 丁二酸 、 草酸 、 溶剂黄146
  参考文献：
  名称：

  Mazza; Calo, Gazzetta Chimica Italiana, 1927, vol. 57, p. 317

  摘要：

  DOI：
• 作为产物：
  描述：

  5,6-dihydro-3H-isobenzofuran-1-one 在 phosphorus 、 氢碘酸 作用下， 生成 6-甲基-环己-1,5-二烯羧酸
  参考文献：
  名称：

  Mazza; Calo, Gazzetta Chimica Italiana, 1927, vol. 57, p. 317

  摘要：

  DOI：

文献信息

• Bis-(2,2,6,6-tetramethyl-piperidyl) diimides as light stabilizers for synthetic polymers
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0313676A1

  公开（公告）日：1989-05-03

  Bis-(2,2,6,6-tetramethyl-piperidyl) diimides are provided, having the formula: in which R is selected from the group consisting of hydrogen; oxyl; alkyl and alkenyl having from one to about eighteen carbon atoms; epoxy and hydroxyalkyl having from two to about eight carbon atoms; acyl having from two to about eight carbon atoms; and phenalkyl having from seven to about twelve carbon atoms; and Z is a tetravalent structure comprising at least one aliphatic and/or at least one cycloaliphatic hydrocarbon group, said hydrocarbon groups may contain at least one ethylenic unsaturation and Z has from two to about eighteen carbon atoms; and stabilizer and synthetic polymer compositions containing such diimides having improved resistance to deterioration when exposed to light.

  双(2,2,6,6-四甲基哌啶基)二亚胺具有以下式子： 其中 R 选自氢、氧基、具有 1 至约 18 个碳原子的烷基和烯基、具有 2 至约 8 个碳原子的环氧基和羟烷基、具有 2 至约 8 个碳原子的酰基和具有 7 至约 12 个碳原子的苯烷基组成的组；Z是四价结构，包括至少一个脂肪族和/或至少一个环脂族烃基，所述烃基可能含有至少一个乙烯基不饱和度，且Z具有2至约18个碳原子；以及含有此类二亚胺的稳定剂和合成聚合物组合物，在暴露于光照时具有更好的抗变质性能。
• Aqueous composition suitable for cleaning and protection comprising silica nanoparticles, copolymer of acrylamide and acrylic acid, nonionic and anionic surfactant
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10273435B2

  公开（公告）日：2019-04-30

  Compositions include a water-soluble polymer, silica nanoparticles, and a combination of a nonionic and anionic dispersed in an aqueous liquid phase. The polymer is a water-soluble copolymer of acrylic acid and an acrylamide, or a salt of the same. Methods of using the compositions to clean and coat a substrate are also disclosed.

  组合物包括水溶性聚合物、二氧化硅纳米颗粒以及分散在水性液相中的非离子和阴离子组合。聚合物是丙烯酸和丙烯酰胺的水溶性共聚物或其盐。此外，还公开了使用这些组合物清洁和涂覆基质的方法。
• Articles, coating compositions, and methods
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10297698B2

  公开（公告）日：2019-05-21

  There is provided a coating composition comprising nonspherical nanoparticles; spherical nanoparticles; optionally hydrophilic groups and optional an surfactant; and a liquid medium comprising water and no greater than 30 wt % organic solvent, if present, based on the total weight of liquid medium, where at least a portion of the nonspherical nanoparticles or at least a portion of the spherical nanoparticles comprises functional groups attached to their surface through chemical bonds, wherein the functional groups comprise at least one group selected from the group consisting of epoxy group, amine group, hydroxyl, olefin, alkyne, (meth) acrylato, mercapto group, or combinations thereof. There is also provided a method for modifying a substrate surface using the coating composition and articles made therefrom.

  提供了一种涂层组合物，包括非球形纳米颗粒、球形纳米颗粒、亲水基团和表面活性剂；和液体介质，其中液体介质包括水和不大于 30 wt％的有机溶剂（如果存在）（基于液体介质的总重量），其中至少一部分非球形纳米颗粒或至少一部分球形纳米颗粒包括通过化学键连接到其表面的官能团，其中官能团包括至少一个选自环氧基、胺基、羟基、烯烃、炔烃、（甲基）丙烯酸酯、巯基或其组合的基团。此外，还提供了一种使用该涂料组合物修饰基材表面的方法及其制成的物品。
• Composition suitable for protection comprising copolymer and hydrophilic silane
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US10414941B2

  公开（公告）日：2019-09-17

  Compositions include a water-soluble copolymer, a hydrophilic silane compound, and in some embodiments surfactant dispersed in a liquid phase. Methods of using the compositions to coat and optionally clean a substrate are also disclosed.

  组合物包括分散在液相中的水溶性共聚物、亲水性硅烷化合物和表面活性剂。此外，还公开了使用这些组合物涂覆和清洁基底的方法。
• EGFR proteolysis targeting chimeric molecules and associated methods of use
  申请人：Arvinas Operations, Inc.

  公开号：US10994015B2

  公开（公告）日：2021-05-04

  The present disclosure relates to bifunctional compounds, which find utility as modulators of receptor tyrosine kinase (RTK) proteins. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand which binds to an E3 ubiquitin ligase and on the other end a moiety which binds a target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effectuate ubiquitination, and therefore, degradation (and inhibition) of the target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作受体酪氨酸激酶（RTK）蛋白的调节剂。特别是，本公开涉及双功能化合物，其一端含有与 E3 泛素连接酶结合的配体，另一端含有与靶蛋白结合的分子，从而使靶蛋白靠近泛素连接酶以实现泛素化，进而降解（和抑制）靶蛋白。本公开内容展示了与靶蛋白降解/抑制相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防因目标蛋白聚集或积聚而导致的疾病或失调。