(2R)-3,4-bis(but-3-enoxy)-2-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-2H-furan-5-one | 876009-74-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R)-3,4-bis(but-3-enoxy)-2-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-2H-furan-5-one
• CAS: 876009-74-4
• 化学式: C₂₀H₂₈O₆
• 分子量: 364.439
• InChiKey: ONHNOEOJZWTNIL-JKSUJKDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2R)-3,4-bis(but-3-enoxy)-2-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-2H-furan-5-one 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives

  摘要：

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.102
• 作为产物：
  描述：

  4-溴-1-丁烯 、 (+)-5,6-O-环亚己基-l-抗坏血酸 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 丁酮 为溶剂， 以19%的产率得到(2R)-3,4-bis(but-3-enoxy)-2-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-2H-furan-5-one
  参考文献：
  名称：

  Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives

  摘要：

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.102

文献信息

• Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives
  作者：Sébastien Redon、Olivier Piva

  DOI：10.1016/j.tetlet.2005.11.102

  日期：2006.1

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.