(4Z,11R)-11-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-3,6,7,11-tetrahydro-2H-furo[3,4-b][1,4]dioxecin-9-one | 876009-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奥昔康唑
• 英文名称: (4Z,11R)-11-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-3,6,7,11-tetrahydro-2H-furo[3,4-b][1,4]dioxecin-9-one
• CAS: 876009-79-9
• 化学式: C₁₈H₂₄O₆
• 分子量: 336.385
• InChiKey: KDNPXBVRYQBEFM-CIKQRIOISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4Z,11R)-11-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-3,6,7,11-tetrahydro-2H-furo[3,4-b][1,4]dioxecin-9-one 以 乙腈 为溶剂， 以80%的产率得到
  参考文献：
  名称：

  Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives

  摘要：

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.102
• 作为产物：
  描述：

  (+)-5,6-O-环亚己基-l-抗坏血酸 在 Grubbs catalyst first generation 、 四丁基碘化铵 、 potassium carbonate 作用下， 以 二氯甲烷 、 丁酮 为溶剂， 生成 (4Z,11R)-11-[(3S)-1,4-dioxaspiro[4.5]decan-3-yl]-3,6,7,11-tetrahydro-2H-furo[3,4-b][1,4]dioxecin-9-one
  参考文献：
  名称：

  Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives

  摘要：

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.102

文献信息

• Diastereoselective transannular [2+2] photocycloaddition of ascorbic acid derivatives
  作者：Sébastien Redon、Olivier Piva

  DOI：10.1016/j.tetlet.2005.11.102

  日期：2006.1

  Ring-closing metathesis of bis-O,O-alkenyl ascorbic acid derivatives affords cyclic ethers in good yields which can be further converted by irradiation at 254 nm into new polyoxacyclic structures according to a diastereoselective transannular [2+2] photocycloaddition. (c) 2005 Elsevier Ltd. All rights reserved.