3,3''-biflavone | 6880-06-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3,3''-biflavone
• 英文别名: 2,2'-diphenyl-[3,3']bichromenyl-4,4'-dione；2,2'-Diphenyl-[3,3']bichromenyl-4,4'-dion；biflavone；3-(4-oxo-2-phenylchromen-3-yl)-2-phenylchromen-4-one
• CAS: 6880-06-4
• 化学式: C₃₀H₁₈O₄
• 分子量: 442.471
• InChiKey: UFJORDZSBNSRQT-UHFFFAOYSA-N

物化性质

• 熔点：
  285-287 °C
• 沸点：
  551.7±50.0 °C(Predicted)
• 密度：
  1.348±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲酰(2-羟基苯酰)甲烷 在 吡啶 、 盐酸 、 ammonium cerium (IV) nitrate 作用下， 以 甲醇 为溶剂， 反应 14.0h， 生成 3,3''-biflavone
  参考文献：
  名称：

  Synthesis and discovery of (I-3,II-3)-biacacetin as a novel non-zinc binding inhibitor of MMP-2 and MMP-9

  摘要：

  Eleven biflavones (7a-b and 9a-i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor. Molecular docking studies suggest that unlike most of the known inhibitors, 9h inhibits MMP-2 and MMP-9 through non-zinc binding interactions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.03.084

文献信息

• Study on the Synthesis of Some New Biflavonoids. VIII. A New Synthesis of C₃-Linked Biflavones, Bithioflavones and Bithiochromones
  作者：Yu Lin Li、Fang Jie Zhang

  DOI：10.1080/00397919308018584

  日期：1993.4

  Abstract Reactions of the 3—iodo derivatives of flavones, thioflavones and thiochromones with finely divided copper at 200–210°C gave the title compounds respectively. Thus a new way to these compounds was provided.

  摘要 黄酮、硫代黄酮和硫代色酮的 3-碘衍生物与细碎的铜在 200–210°C 下反应分别得到标题化合物。因此为这些化合物提供了一种新方法。
• Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
  申请人：Nimni Marcel

  公开号：US20060045926A1

  公开（公告）日：2006-03-02

  A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

  一种用于皮肤的组合物可以刺激胶原蛋白和蛋白多糖的体内合成，改善皮肤外观，增加皮肤的弹性和饱满度。一般来说，根据本发明的组合物包括：(1) 抗氧化剂化合物，其含量足以促进皮肤中胶原蛋白的合成；(2) 有机渗透剂，其中抗氧化剂化合物的溶解度足以使足以促进胶原蛋白合成的抗氧化剂化合物浓度局部使用并渗透皮肤；(3) 必需氨基酸混合物；(4) 硫的补充来源；(5) 局部用药可接受的载体。抗氧化剂化合物可以是硫辛酸、硫辛酸类似物或衍生物、生物类黄酮、银杏成分或异黄酮。有机渗透剂最好是苯甲醇。也可加入其他成分，如生育酚酯和抗坏血酸酯。
• Compositions and methods for treatment of solar damage
  申请人：Nimni Marcel

  公开号：US20060067959A1

  公开（公告）日：2006-03-30

  An improved composition for treatment of the skin comprises: (1) methionine and cysteine in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (2) a mixture of essential amino acids in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin, the mixture comprising isoleucine, leucine, lysine, phenylalanine, threonine, tryptophan, valine, histidine, and arginine; (3) at least one antioxidant in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (4) at least one cross-linking agent in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (5) at least one metallic catalyst in a quantity sufficient to accelerate restoration of the integrity and fullness of the skin; (6) at least one transepidermal delivery agent in a quantity sufficient to promote delivery of the composition to the skin; and (7) a topical pharmaceutically acceptable carrier. The antioxidant can be ascorbic acid. The cross-linking agent can be proanthocyanidin or silybin. The metallic catalyst can be Cu (II) in a suitable cupric salt. The transepidermal delivery agent can be benzyl alcohol.

  一种用于治疗皮肤的改良组合物包括(1) 蛋氨酸和半胱氨酸，其含量足以加速恢复皮肤的完整性和饱满度；(2) 必需氨基酸混合物，其含量足以加速恢复皮肤的完整性和饱满度，该混合物包括异亮氨酸、亮氨酸、赖氨酸、苯丙氨酸、苏氨酸、色氨酸、缬氨酸、组氨酸和精氨酸；(3) 至少一种抗氧化剂，其含量足以加速恢复皮肤的完整性和饱满度；(4) 至少一种交联剂，其用量应足以加速恢复皮肤的完整性和饱满度； (5) 至少一种金属催化剂，其用量应足以加速恢复皮肤的完整性和饱满度； (6) 至少一种经表皮递送剂，其用量应足以促进将组合物递送至皮肤；以及 (7) 外用药学上可接受的载体。抗氧化剂可以是抗坏血酸。交联剂可以是原花青素或水飞蓟宾。金属催化剂可以是合适的铜盐中的铜（II）。经皮给药剂可以是苯甲醇。
• Synthesis and antifungal activities of natural and synthetic biflavonoids
  作者：Gabriel Sagrera、Ana Bertucci、Alvaro Vazquez、Gustavo Seoane

  DOI：10.1016/j.bmc.2011.04.010

  日期：2011.5

  The synthesis of some natural and synthetic biflavonoids was performed in good overall yields starting from readily available materials via high yielding aldol and Ullmann condensations. Some of these compounds, especially bichalcones, display an interesting activity against fungi, higher than that of the corresponding monomers. (C) 2011 Elsevier Ltd. All rights reserved.
• Chen; Liu, Taiwan Yaoxue Zazhi, 1953, vol. 5, p. 53
  作者：Chen、Liu

  DOI：——

  日期：——