5-(N-(benzyloxycarbonyl)sarcosinamido)-5-hydroxymethyl-2-phenyl-1,3-dioxane | 159945-08-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(N-(benzyloxycarbonyl)sarcosinamido)-5-hydroxymethyl-2-phenyl-1,3-dioxane
• CAS: 159945-08-1
• 化学式: C₂₁H₂₄N₂O₆
• 分子量: 400.431
• InChiKey: HYZQJSBFKGZRBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.51
• 重原子数：
  29.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  106.12
• 氢给体数：
  3.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  5-(N-(benzyloxycarbonyl)sarcosinamido)-5-hydroxymethyl-2-phenyl-1,3-dioxane 在 palladium on activated charcoal 4-二甲氨基吡啶 、 calcium sulfate 、 氢气 、 sodium methylate 、 氰化汞 、 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 溶剂黄146 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 8.25h， 生成
  参考文献：
  名称：

  Vesicles and other supramolecular systems made from double-tailed synthetic glycolipids derived from galactosylated tris(hydroxymethyl)aminomethane

  摘要：

  A series of double-tailed hydrocarbon glycolipids derived from tris(hydroxymethyl)aminomethane (Tris) have been prepared. These amphiphiles consist of three parts: a hydrophilic head derived from mono- or polygalactosylated Tris, a linking arm of peptidic nature and a hydrophobic double tail composed of 12 or 18 carbon atom chains. The ability of the new glycolipids to disperse in water, the morphology of the self-assemblies they form and the stability of the latter were shown to depend largely on the volumetric ratio between hydrophilic head and hydrophobic tails. Comparative studies of such substrates allowed a better understanding of the relative role of the various parameters that govern the formation of tubular systems relative to vesicular organizations. In all cases, the introduction of oligomeric galactosylated heads favoured stable vesicular systems over tubules.

  DOI：

  10.1016/0009-3084(95)02475-x
• 作为产物：
  描述：

  N-苄氧羰基甘氨酸 在 对甲苯磺酸 、 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 5.17h， 生成 5-(N-(benzyloxycarbonyl)sarcosinamido)-5-hydroxymethyl-2-phenyl-1,3-dioxane
  参考文献：
  名称：

  Synthesis of double-chain glycolipids derived from aspartic acid : Preliminary investigation of their colloidal behavior

  摘要：

  Double-tailed glycolipids derived from mono-, di- and tri-O-galactosyl tris-(hydroxymethyl) aminomethane and aspartic acid have been synthesized. Preliminary assessment by negative staining transmission electron microscopy of dispersions of these amphiphiles showed the formation of either vesicles, helical structures or fibers depending on the glycolipid structure.

  DOI：

  10.1016/s0040-4039(00)76654-8