1-[4-(4-chloro-2-methylphenoxy)-6-methylpyridin-3-yl]-N,N-dimethylmethanamine | 1036334-41-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-(4-chloro-2-methylphenoxy)-6-methylpyridin-3-yl]-N,N-dimethylmethanamine
• CAS: 1036334-41-4
• 化学式: C₁₆H₁₉ClN₂O
• 分子量: 290.793
• InChiKey: CTPBZYGSXVZQMN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  25.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 1-[4-(4-chloro-2-methylphenoxy)-6-methylpyridin-3-yl]-N-methylmethanamine 在 三乙酰氧基硼氢化钠 作用下， 以 二氯甲烷 为溶剂， 生成 1-[4-(4-chloro-2-methylphenoxy)-6-methylpyridin-3-yl]-N,N-dimethylmethanamine
  参考文献：
  名称：

  Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity

  摘要：

  A novel series of pyridyl-phenyl ethers are disclosed, which possess dual 5-HT and NA reuptake pharmacology with good selectivity over dopamine reuptake inhibition. An analysis of the relationship between lipophilicity and pharmacology highlighted that potent dual SNRI activity was only achievable at c log P > 3.5. The series was found to possess significant polypharmacology issues, and we concluded that this off-target promiscuity was related to lipophilicity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.03.082

文献信息

• Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
  作者：Gavin A. Whitlock、Paul V. Fish、M. Jonathan Fray、Alan Stobie、Florian Wakenhut

  DOI：10.1016/j.bmcl.2008.03.082

  日期：2008.5

  A novel series of pyridyl-phenyl ethers are disclosed, which possess dual 5-HT and NA reuptake pharmacology with good selectivity over dopamine reuptake inhibition. An analysis of the relationship between lipophilicity and pharmacology highlighted that potent dual SNRI activity was only achievable at c log P > 3.5. The series was found to possess significant polypharmacology issues, and we concluded that this off-target promiscuity was related to lipophilicity. (C) 2008 Elsevier Ltd. All rights reserved.