Anilinoimidazo[4,5-g]quinoline 20b

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Anilinoimidazo[4,5-g]quinoline 20b
• 英文别名: 8-(5-methoxy-2-methylanilino)-3-(2-morpholin-4-ylethyl)imidazo[4,5-g]quinoline-7-carbonitrile
• 化学式: C₂₅H₂₆N₆O₂
• 分子量: 442.52
• InChiKey: QZNNCWRNJVXQIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-[2-(4-morpholinyl)ethyl]-8-oxo-5,8-dihydro-3H-imidazo[4,5-g]quinoline-7-carbonitrile 在 草酰氯 、 吡啶盐酸盐 作用下， 以 乙二醇乙醚 为溶剂， 生成 Anilinoimidazo[4,5-g]quinoline 20b
  参考文献：
  名称：

  8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors

  摘要：

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00524-3

文献信息

• 8-Anilinoimidazo[4,5-g]quinoline-7-carbonitriles as Src Kinase Inhibitors
  作者：Dan Berger、Minu Dutia、Dennis Powell、Biqi Wu、Allan Wissner、Frenel DeMorin、Jennifer Weber、Frank Boschelli

  DOI：10.1016/s0960-894x(02)00524-3

  日期：2002.10

  A series of 8-anilinoimidazo[4,5-g]quinoline-7-carbonitriles was synthesized and evaluated as Src kinase inhibitors. Several aniline substituents were surveyed, as well as water-solubilizing groups at the C-2 and N-3 positions. Potent Src inhibitors were identified, with N-3 providing the best position for an additional water-solubilizing group. (C) 2002 Elsevier Science Ltd. All rights reserved.