3--1-(4-methylphenyl)-1-propanone | 65473-20-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3--1-(4-methylphenyl)-1-propanone
• 英文别名: beta-(N-methyl-(1-naphthylmethyl)amino]ethyl-(4-tolyl)ketone；3-[methyl(naphthalen-1-ylmethyl)amino]-1-(4-methylphenyl)propan-1-one
• CAS: 65473-20-3
• 化学式: C₂₂H₂₃NO
• 分子量: 317.431
• InChiKey: SBMUBYMSJHYBFI-UHFFFAOYSA-N

物化性质

• 沸点：
  477.9±33.0 °C(Predicted)
• 密度：
  1.098±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3--1-(4-methylphenyl)-1-propanone 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以79%的产率得到3--1-(4-methylphenyl)-1-propanol
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

  摘要：

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.

  DOI：

  10.1021/jm00151a019
• 作为产物：
  描述：

  (氯甲基)萘 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 3--1-(4-methylphenyl)-1-propanone
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics

  摘要：

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.

  DOI：

  10.1021/jm00151a019

文献信息

• Trans-n-cinnamyl-n-methyl-(1-naphthylmethyl)amine
  申请人：Sandoz Ltd.

  公开号：US04282251A1

  公开（公告）日：1981-08-04

  Cinnamylalkyl-1-naphthylmethylamines, useful as antimycotic agents, and processes for their production.

  肉桂基烷基-1-萘甲胺，可用作抗真菌剂，以及其生产过程。
• US4282251A
  申请人：——

  公开号：US4282251A

  公开（公告）日：1981-08-04
• Synthesis and structure-activity relationships of naftifine-related allylamine antimycotics
  作者：Anton Stuetz、Apostolos Georgopoulos、Waltraud Granitzer、Gabor Petranyi、Daniel Berney

  DOI：10.1021/jm00151a019

  日期：1986.1

  Naftifine (1) is the first representative of the new antifungal allylamine derivatives. Its biological activity is strictly bound to specific structural requirements that are unrelated to those of known antifungals. A tertiary allylamine function seems to be a prerequisite for activity against fungi. By systematic variation of the individual structural elements in 1, detailed structure-activity relationships are defined in which the phenyl ring is the structural feature permitting the widest variations. Versatile synthetic routes to allylamine derivatives and comparative biological data are presented.