2-氰基-6-甲氧基哌嗪 | 136309-07-4

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡嗪类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-氰基-6-甲氧基哌嗪
• 中文别名: 2-甲氧基-6-氰基吡嗪
• 英文名称: 2-Cyano-6-methoxypyridine
• 英文别名: 6-methoxy-pyrazine-2-carbonitrile；6-Methoxypyrazine-2-carbonitrile
• CAS: 136309-07-4
• 化学式: C₆H₅N₃O
• mdl: MFCD10697785
• 分子量: 135.125
• InChiKey: HJMUXUUZHUCKFP-UHFFFAOYSA-N

物化性质

• 沸点：
  229℃
• 密度：
  1.24
• 闪点：
  92℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  58.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-氰基-6-甲氧基哌嗪 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二乙二醇二甲醚 为溶剂， 反应 0.75h， 生成 N'-(4-aminophenylsulfonyl)-6-methoxypyrazine-2-carboximidamide
  参考文献：
  名称：

  Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides

  摘要：

  A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the alpha position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal..

  DOI：

  10.1007/s00706-012-0769-6
• 作为产物：
  描述：

  三甲基氰硅烷 、 3-甲氧基吡嗪 1-氧化物 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以43%的产率得到3-甲氧基吡嗪-2-甲腈
  参考文献：
  名称：

  Sato, Nobuhiro; Shimomura, Yuji; Ohwaki, Yoshie, Journal of the Chemical Society. Perkin transactions I, 1991, # 11, p. 2877 - 2882

  摘要：

  DOI：

文献信息

• Synthesis and biological activity of novel 3-heteroaryl-2H-pyrido[4,3-e][1,2,4]thiadiazine and 3-heteroaryl-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxides
  作者：Katarzyna Gobis、Henryk Foks、Jarosłw Sławiński、Ewa Augustynowicz-Kopeć、Agnieszka Napiórkowska

  DOI：10.1007/s00706-013-0988-5

  日期：2013.8

  ABSTRACT: A series of novel 1,2,4-thiadiazine 1,1-dioxides were synthesized by condensation of 2-chlorobenzenesulfonamide and 4-chloropyridine-3-sulfonamide with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used at the time of their creation. Substituted amidines were isolated as the intermediates in the reaction with 2-chlorobenzenesulfonamide. Those intermediates

  摘要：通过将2-氯苯磺酰胺和4-氯吡啶-3-磺酰胺与从杂环腈中获得的杂环甲基氨基甲酸酯缩合，合成了一系列新型的1,2,4-噻二嗪1,1-二氧化物。 。分离出取代的am作为与2-氯苯磺酰胺反应的中间体。加入DBU，将这些中间体成功地环化成吡啶中的相应1,2,4-噻二嗪1,1-二氧化物。对新合成的化合物的抗结核和抗癌活性进行了评估。八种化合物能够抑制某些肾脏和非小细胞肺癌细胞系的生长。图形概要：
• Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides
  作者：Katarzyna Gobis、Henryk Foks、Katarzyna Wiśniewska、Maria Dąbrowska-Szponar、Ewa Augustynowicz-Kopeć、Agnieszka Napiórkowska、Artur Sikorski

  DOI：10.1007/s00706-012-0769-6

  日期：2012.8

  A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the alpha position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal..
• Sato, Nobuhiro; Shimomura, Yuji; Ohwaki, Yoshie, Journal of the Chemical Society. Perkin transactions I, 1991, # 11, p. 2877 - 2882
  作者：Sato, Nobuhiro、Shimomura, Yuji、Ohwaki, Yoshie、Takeuchi, Ryo

  DOI：——

  日期：——