3α,6α-dihydroxy-5β-(22R,23R,24S)-22,23-isopropylidenedioxy-24,25-dimethyl-cholestane | 141069-83-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α,6α-dihydroxy-5β-(22R,23R,24S)-22,23-isopropylidenedioxy-24,25-dimethyl-cholestane
• 英文别名: (22R,23R)-22,23-isopropylidenedioxy-25-methyl-5β-erogstane-3α,6α-diol；(3R,5R,6S,8S,9S,10R,13S,14S,17R)-17-[(1S)-1-[(4R,5R)-5-[(2S)-3,3-dimethylbutan-2-yl]-2,2-dimethyl-1,3-dioxolan-4-yl]ethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol
• CAS: 141069-83-2
• 化学式: C₃₂H₅₆O₄
• 分子量: 504.794
• InChiKey: GKDFIXUSMFNZKL-DCUVZIMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.82
• 重原子数：
  36.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  3α,6α-dihydroxy-5β-(22R,23R,24S)-22,23-isopropylidenedioxy-24,25-dimethyl-cholestane 在 silica gel 、 copper(II) sulfate 盐酸 、 四氧化锇 、 重铬酸吡啶 、 sodium methylate 、 potassium carbonate 、 potassium hexacyanoferrate(III) 作用下， 以 四氢呋喃 、 甲醇 、 四氯乙烯 、 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 69.5h， 生成 25-methylcastasterone
  参考文献：
  名称：

  Studies on steroidal plant-growth regulator 25. Concise stereoselective construction of sidechain of brassinosteroid from the intact sidechain of hyodeoxycholic acid: formal syntheses of brassinolide, 25-methylbrassinolide, 26, 27-bisnorbrassinolide and their related compounds

  摘要：

  A concise stereoselective construction of sidechain of brassinolide (1), 25-methylbrassinolide (3) and 26,27-bisnorbrassinolide (4), which involves beta-alkylative 1,3- carbonyl transposition of the alpha,beta-unsaturated ketones 11 and 34 and alpha, beta-unsaturated methyl ester 26, using the intact sidechain of hyodeoxycholic acid (2) as starting material, is described. The formal syntheses of 1, 3 and 4 were accomplished. In the mean time, 25-methylcastasterone (21), 26,27-bisnortyphasterol (6) and the new 25-methyltyphasterol (5) were also syntehesized.

  DOI：

  10.1016/s0040-4020(01)88509-4
• 作为产物：
  描述：

  (22R,23R,24S)-22,23-dihydroxy-3α,6α-dimethoxymethyloxy-5β-24,25-dimethyl-cholestane 在 4-甲基苯磺酸吡啶 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 7.0h， 生成 3α,6α-dihydroxy-5β-(22R,23R,24S)-22,23-isopropylidenedioxy-24,25-dimethyl-cholestane
  参考文献：
  名称：

  Studies on steroidal plant-growth regulator 25. Concise stereoselective construction of sidechain of brassinosteroid from the intact sidechain of hyodeoxycholic acid: formal syntheses of brassinolide, 25-methylbrassinolide, 26, 27-bisnorbrassinolide and their related compounds

  摘要：

  A concise stereoselective construction of sidechain of brassinolide (1), 25-methylbrassinolide (3) and 26,27-bisnorbrassinolide (4), which involves beta-alkylative 1,3- carbonyl transposition of the alpha,beta-unsaturated ketones 11 and 34 and alpha, beta-unsaturated methyl ester 26, using the intact sidechain of hyodeoxycholic acid (2) as starting material, is described. The formal syntheses of 1, 3 and 4 were accomplished. In the mean time, 25-methylcastasterone (21), 26,27-bisnortyphasterol (6) and the new 25-methyltyphasterol (5) were also syntehesized.

  DOI：

  10.1016/s0040-4020(01)88509-4

文献信息

• Zhou, Wei-Shan; Huang, Liang-Fu; Sun, Li-Qiang, Journal of the Chemical Society. Perkin transactions I, 1992, # 15, p. 2039 - 2044
  作者：Zhou, Wei-Shan、Huang, Liang-Fu、Sun, Li-Qiang、Pan, Xin-Fu

  DOI：——

  日期：——