2-benzyl-7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-2-benzazepine | 253135-14-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 2-benzyl-7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-2-benzazepine
• 英文别名: 2-benzyl-8-methoxy-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-ol；2-Benzyl-8-methoxy-1,3,4,5-tetrahydro-2-benzazepin-7-ol
• CAS: 253135-14-7
• 化学式: C₁₈H₂₁NO₂
• 分子量: 283.37
• InChiKey: PDDCWQCIBRIMRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-benzyl-7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-2-benzazepine 在 palladium 10% on activated carbon 、 氢溴酸 、 氢气 作用下， 以 甲醇 为溶剂， 生成 7,8-二羟基-2,3,4,5-四氢-2-苯并氮杂卓,氢溴酸盐
  参考文献：
  名称：

  TRPV1通道的光学控制

  摘要：

  用光控制疼痛：TRPV1通道介导对有害热量的反应，并可以被辣椒的主要成分辣椒素激活。新型偶氮苯光电开关可用于TRPV1的光学控制。这些化合物中的一种以光依赖的方式拮抗辣椒素，表明可光转换的拮抗剂和激动剂可以协同使用以调节离子通道活性。

  DOI：

  10.1002/anie.201302530
• 作为产物：
  描述：

  isoferulic acid methyl ester 在 palladium on activated charcoal sodium hydroxide 、 lithium aluminium tetrahydride 、 甲烷磺酸 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 乙腈 为溶剂， 反应 54.0h， 生成 2-benzyl-7-hydroxy-8-methoxy-2,3,4,5-tetrahydro-2-benzazepine
  参考文献：
  名称：

  A Facile and Practical Synthesis of Capsazepine, a Vanilloid Receptor Antagonist

  摘要：

  A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist, has been accomplished from isovanillin in 8 steps via an efficient intramolecular Mannich cyclization.

  DOI：

  10.1080/00397919908085886

文献信息

• COMPOUND
  申请人：Jourdan Fabrice

  公开号：US20100222299A1

  公开（公告）日：2010-09-02

  The present invention involves tetrahydroisoquinoline compounds and their use in the inhibition and/or prevention of tumor growth.

  本发明涉及四氢异喹啉化合物及其在抑制和/或预防肿瘤生长中的应用。
• TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS
  申请人：Sterix Limited

  公开号：EP2155192A2

  公开（公告）日：2010-02-24
• US8394825B2
  申请人：——

  公开号：US8394825B2

  公开（公告）日：2013-03-12
• [EN] COMPOUND<br/>[FR] COMPOSÉ
  申请人：STERIX LTD

  公开号：WO2008117061A2

  公开（公告）日：2008-10-02

  [EN] The present invention provides a compound of Formula (I) or Formula (Il) wherein A is selected from CR₁₀R₁₁, -S(=O)₂-, -NR₁₂-,and C=O, wherein R₁₀ and R₁₁ independently selected from H, -OH, hydrocarbyl, -CN, -NO₂, and halogens, R₁₂ is selected from H and hydrocarbyl; B is selected from (CR₁₃R₁₄)_1-3, C=O, CR₁₅R₁₆C=O, -S(=O)₂-, -NR₁₇- and -NR₁₈-C(=O)-, wherein each of R₁₃, R₁₄, R₁₅ and R₁₆ is independently selected from H, -OH, hydrocarbyl, -CN, -NO₂, and halogens, R₁₇ and R₁₈ are independently selected from H and hydrocarbyl; R₁ is selected from OH, O-hydrocarbyl, O-heterohydrocarbyl, -SO₂-hydrocarbyl, -CH=CH₂, halogen, -OSO₂NR₁₉R₂₀, -C(=O)-NR₂₁R₂₂, -NR₂₃-C(=O)H and -NR₃₅R₃₆; wherein each of R₁₉, R₂₀, R₂₁, R₂₂, R₂₃, R₃₅ and R₃₆ is independently is selected from H and hydrocarbyl; R₂ is selected from H, -O-hydrocarbyl, -S-hydrocarbyl, hydrocarbyl, -CN, -NO₂, and halogens, R₃ is selected from Formula (A), Formula (B), Formula (C), Formula (D) wherein each of R₄, R₅, R₆, R₇ and R₈ is independently selected from H, -OH, hydrocarbyl, -O-hydrocarbyl, -COOH or an ester thereof, halocarbyl, -O-halocarbyl, acyl, -O-acyl, -NR₂₉-acyl, -O-SO₂NR₁₉R₂₀, -NR₃₀R₃₁, -NR₃₂SO₂R₃₃, -CN, -NO₂, and halogens, R₉ is selected from H and hydrocarbyl, and each R₂₉ to R₃₃ is independently selected from H and hydrocarbyl; and wherein two or more of R₄, R₅, R₆, R₇, R₈ and R₉ may together form a ring; wherein when R₁ is OH and R₃ is of Formula (D), (i) at least one of R₄, R₅, R₆, R₇ and R₈ is independently selected from halocarbyl, -O-halocarbyl, -O-acyl, -NR₂₉-acyl, -O- SO₂NR₁₉R₂₀, -NR₃₀R₃₁, -NR₃₂SO₂R₃₃, -CN, and halogens, or (ii) two or more of R₄, R₅, R₆, R₇ and R₈ together form a ring, or (iii) at least three of R₄, R₅, R₆, R₇ and R₈ are independently selected from -OH, hydrocarbyl, -O-hydrocarbyl, halocarbyl, -O-halocarbyl, -O-acyl, -NR₂₉-acyl, -O-SO₂NR₁₉R₂₀, -NR₃₀R₃₁, -NR₃₂SO₂R₃₃, -CN, -NO₂, and halogens; wherein h is an optional bond, wherein G is CR₂₄R₂₅, wherein R₂₄ and R₂₅ independently selected from H, -OH, hydrocarbyl, -CN, -NO₂, and halogens, or wherein when h is present G is CR₂₄, wherein R₂₄ is selected from H, -OH, hydrocarbyl, -CN, -NO₂, and halogens; n is 0, 1 or 2, each D is independently selected from O, NR₂₆ and CR₂₇R₂₈, wherein each R₂₆ is independently selected from H and hydrocarbyl; and each R₂₇ and R₂₈ is independently selected from H, -OH, hydrocarbyl, -CN, -NO₂, and halogens.
  [FR] La présente invention concerne un composé de formule (I) ou de formule (II) dans lesquelles A est choisi parmi CR₁₀R₁₁, -S(=O)₂-, -NR₁₂-, et C=O, R₁₀ et R₁₁ étant indépendamment choisis parmi H, -OH, un groupe hydrocarbyle, -CN, -NO₂, et des atomes d'halogène, et R₁₂ étant choisi parmi H et un groupe hydrocarbyle; B est choisi parmi (CR₁₃R₁₄)_1-3, C=0, CR₁₅R₁₆C=O, -S(=O)₂-, -NR₁₇- et -NR₁₈-C(=O)-, chacun de R₁₃, R₁₄, R₁₅ et R₁₆ étant indépendamment choisi parmi H, -OH, un groupe hydrocarbyle, -CN, -NO₂, et des atomes d'halogène, R₁₇
• A Facile and Practical Synthesis of Capsazepine, a Vanilloid Receptor Antagonist
  作者：Jeewoo Lee、Jiyoun Lee

  DOI：10.1080/00397919908085886

  日期：1999.12.1

  A facile and practical synthesis of capsazepine, a vanilloid receptor antagonist, has been accomplished from isovanillin in 8 steps via an efficient intramolecular Mannich cyclization.