2,4-Bis(phenylmethoxy)-1-prop-2-enylbenzene | 115692-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2,4-Bis(phenylmethoxy)-1-prop-2-enylbenzene
• CAS: 115692-62-1
• 化学式: C₂₃H₂₂O₂
• 分子量: 330.426
• InChiKey: RAJKYQWMXVDGNN-UHFFFAOYSA-N

物化性质

• 沸点：
  471.8±40.0 °C(predicted)
• 密度：
  1.089±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,4-Bis(phenylmethoxy)-1-prop-2-enylbenzene 生成 3-[2,4-bis(phenylmethoxy)phenyl]propane-1,2-diol
  参考文献：
  名称：

  CAI, MENG-SHEN;WANG, LAN-MING, XUASYUEH SYUEHBAO, 48,(1990) N2, S. 1191-1198

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二酚 在 sodium hydride 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 3.0h， 生成 2,4-Bis(phenylmethoxy)-1-prop-2-enylbenzene
  参考文献：
  名称：

  The total synthesis of argiopine (argiotoxin-636)

  摘要：

  DOI：

  10.1016/s0040-4039(00)96851-5

文献信息

• Desferrithiocin Analogue Based Hexacoordinate Iron(III) Chelators
  作者：Raymond J. Bergeron、Guangfei Huang、William R. Weimar、Richard E. Smith、Jan Wiegand、James S. McManis

  DOI：10.1021/jm020184n

  日期：2003.1.1

  Traditional thinking has been that hexacoordinate Fe(III) ligands are more effective at preventing iron's interactions with reactive oxygen species, most particularly the Fe(II)-mediated reduction of hydrogen peroxide to the hydroxyl radical (i.e., Fenton chemistry), than are ligands of lower denticity. Thus, a hexacoordinate derivative of the well-characterized tricoordinate ligand (S)-2-(2,4-dihydroxyphenyl)-4,5-dihydro-4-thiazolecarboxylic acid [4'-(HO)-DADMDFT], (S,S)-1,11-bis[5-(4-carboxy-4,5-dihydrothiazol-2-yl)-2,4-dihydroxyphenyl]-4,8-dioxaundecane, was designed with the aid of a molecular modeling program and synthesized, Evaluations both in vitro and in vivo were carried out to determine whether there is any advantage, at the level of prevention of Fenton chemistry, radical trapping, or iron clearance, to constructing a desferrithiocin-based hexacoordinate analogue. The hexacoordinate analogue was more effective at preventing the iron-mediated oxidation of ascorbate at low ligand/metal ratios than was its tricoordinate parent and can function as an excellent radical scavenger. At equivalent iron binding doses in the bile duct cannulated rodent, oral administration of the tricoordinate ligand was Mold more effective than was po administration of the hexacoordinate derivative. However, se administration of the hexacoordinate derivative resulted in an efficiency that was 3 times greater than that of the tricoordinate chelator. Unfortunately, the rodent findings were not substantiated in the primates. The hexacoordinate ligand was only about one-half as efficient as its tricoordinate parent when administered so. Owing to these results, po dosing was not attempted. Thus, there appears to be no overall advantage to coupling two molecules of 4 (HO)-DADMDFT to afford a hexacoordinate derivative.
• SHIH, THOMAS L.;RUIZ-SANCHEZ, JOSE;MROZIK, HELMUT, TETRAHEDRON LETT., 28,(1987) N 48, 6015-6018
  作者：SHIH, THOMAS L.、RUIZ-SANCHEZ, JOSE、MROZIK, HELMUT

  DOI：——

  日期：——