(E)-methyl 3-(2-(2,2-dioxidobenzo[e][1,2,3]oxathiazin-4-yl)phenyl)acrylate | 1609405-77-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-methyl 3-(2-(2,2-dioxidobenzo[e][1,2,3]oxathiazin-4-yl)phenyl)acrylate
• 英文别名: methyl (E)-3-[2-(2,2-dioxo-1,2lambda6,3-benzoxathiazin-4-yl)phenyl]prop-2-enoate；methyl (E)-3-[2-(2,2-dioxo-1,2λ6,3-benzoxathiazin-4-yl)phenyl]prop-2-enoate
• CAS: 1609405-77-7
• 化学式: C₁₇H₁₃NO₅S
• 分子量: 343.36
• InChiKey: NOYCCUMEIPKLGP-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  90.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 4-phenylbenzo[e][1,2,3]oxathiazine 2,2-dioxide 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 copper diacetate 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以76%的产率得到(E)-methyl 3-(2-(2,2-dioxidobenzo[e][1,2,3]oxathiazin-4-yl)phenyl)acrylate
  参考文献：
  名称：

  Aerobic Oxidative C–H Olefination of Cyclic N-Sulfonyl Ketimines Catalyzed by a Rhodium Catalyst

  摘要：

  A useful method for the synthesis of ortho-olefinated ketimines from readily accessible cyclic N-sulfonyl ketimines and various olefins has been achieved. The reactions proceeded by Rh(III)-catalyzed, N-sulfonyl ketimine-directed C-H cleavage under aerobic conditions. Further synthetic transformations of the olefinic products led to interesting heterocyclic molecules.

  DOI：

  10.1021/ol501152a

文献信息

• Aerobic Oxidative C–H Olefination of Cyclic <i>N</i>-Sulfonyl Ketimines Catalyzed by a Rhodium Catalyst
  作者：Nan-Jin Wang、Shu-Tao Mei、Li Shuai、Yi Yuan、Ye Wei

  DOI：10.1021/ol501152a

  日期：2014.6.6

  A useful method for the synthesis of ortho-olefinated ketimines from readily accessible cyclic N-sulfonyl ketimines and various olefins has been achieved. The reactions proceeded by Rh(III)-catalyzed, N-sulfonyl ketimine-directed C-H cleavage under aerobic conditions. Further synthetic transformations of the olefinic products led to interesting heterocyclic molecules.