(Z)-3-(7-methoxy-2-oxo-1H-quinolin-3-yl)prop-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (Z)-3-(7-methoxy-2-oxo-1H-quinolin-3-yl)prop-2-enoic acid
• 化学式: C₁₃H₁₁NO₄
• 分子量: 245.235
• InChiKey: MZBPMKVCJKJLSS-HYXAFXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.63
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  79.39
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (Z)-3-(7-methoxy-2-oxo-1H-quinolin-3-yl)prop-2-enoic acid 在 disodium diselenide 、 硫酸 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 生成 7-methoxy-selenolo[2,3-b]quinoline-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of Selenolo(2,3-b)quinoline-2-carboxylic Ethyl Esters: Cytogenetic Studies on Human Peripheral Blood Leucocyte Cultures, and Anti-Bacterial Studies, and Anti-Fungal Studies of Their Effects

  摘要：

  The compounds selenolo(2,3-b)quinoline-2-carboxylic ethyl esters were synthesized in good yields by the reaction of 3-(2-chloro-3-quinolyl)actylic ethyl esters, with the nucleophilic reagent sodium diselenide in ethanol medium under a nitrogen atmosphere. Cytogenetic studies on human blood leucocytes in vitro were evaluated for some of the synthesized compounds. Most of the synthesized compounds were tested for their antibacterial and antifungal activities.

  DOI：

  10.1080/104265090889512
• 作为产物：
  描述：

  2-氯-7-甲氧基喹啉-3-甲醛 在 哌啶 、 吡啶 、 盐酸 作用下， 生成 (Z)-3-(7-methoxy-2-oxo-1H-quinolin-3-yl)prop-2-enoic acid
  参考文献：
  名称：

  Synthesis of Selenolo(2,3-b)quinoline-2-carboxylic Ethyl Esters: Cytogenetic Studies on Human Peripheral Blood Leucocyte Cultures, and Anti-Bacterial Studies, and Anti-Fungal Studies of Their Effects

  摘要：

  The compounds selenolo(2,3-b)quinoline-2-carboxylic ethyl esters were synthesized in good yields by the reaction of 3-(2-chloro-3-quinolyl)actylic ethyl esters, with the nucleophilic reagent sodium diselenide in ethanol medium under a nitrogen atmosphere. Cytogenetic studies on human blood leucocytes in vitro were evaluated for some of the synthesized compounds. Most of the synthesized compounds were tested for their antibacterial and antifungal activities.

  DOI：

  10.1080/104265090889512

文献信息

• Synthesis of Selenolo(2,3-b)quinoline-2-carboxylic Ethyl Esters: Cytogenetic Studies on Human Peripheral Blood Leucocyte Cultures, and Anti-Bacterial Studies, and Anti-Fungal Studies of Their Effects
  作者：V. Nithyadevi、S. P. Rajendran

  DOI：10.1080/104265090889512

  日期：2005.8.1

  The compounds selenolo(2,3-b)quinoline-2-carboxylic ethyl esters were synthesized in good yields by the reaction of 3-(2-chloro-3-quinolyl)actylic ethyl esters, with the nucleophilic reagent sodium diselenide in ethanol medium under a nitrogen atmosphere. Cytogenetic studies on human blood leucocytes in vitro were evaluated for some of the synthesized compounds. Most of the synthesized compounds were tested for their antibacterial and antifungal activities.