2,3-dimethyl-5,6-dihydroxyindole | 5107-75-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,3-dimethyl-5,6-dihydroxyindole
• 英文别名: 5,6-dihydroxy-2,3-dimethylindole；2,3-dimethyl-5,6-hydroxyindole；2,3-dimethyl-indole-5,6-diol；2,3-Dimethyl-indol-5,6-diol；2,3-dimethyl 5,6-dihydroxyindole；2,3-dimethyl-5,6-dihydroxyindol；2,3-Dimethyl-1H-indole-5,6-diol
• CAS: 5107-75-5
• 化学式: C₁₀H₁₁NO₂
• 分子量: 177.203
• InChiKey: HMTUVSJLXALWIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.2
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2,3-dimethyl-5,6-dihydroxyindole 在 邻四氯苯醌 作用下， 以 甲醇 为溶剂， 生成 2,3-dimethyl-5,6-indolequinone
  参考文献：
  名称：

  瞬态5,6-吲哚醌的首次表征

  摘要：

  5,6-二羟基-2,3-二甲基吲哚（氧化1）用的NaIO 4或ö -chloranil得到黄色瞬态与中间λ最大周围360纳米，其被鉴定为迄今未知的2,3-二甲基-5,6- -吲哚醌（2）通过简单的1 H-NMR分析。

  DOI：

  10.1016/0040-4039(96)00806-4
• 作为产物：
  描述：

  3,4-二甲氧基苯肼盐酸盐 在 aluminum tri-bromide 、 乙醇 、 sodium acetate 、 溶剂黄146 、 苯 作用下， 生成 2,3-dimethyl-5,6-dihydroxyindole
  参考文献：
  名称：

  Beer et al., Journal of the Chemical Society, 1949, p. 2061,2064

  摘要：

  DOI：

文献信息

• THIOL DYES
  申请人：Eliu Victor Paul

  公开号：US20090113639A1

  公开（公告）日：2009-05-07

  Disclosed are thiol dyes of formula (1), wherein R 1 is hydrogen; C 1 -C 12 alkyl; or phenyl-C 1 -C 4 alkyl; X is C 1 -C 12 alkylene; C 2 -C 12 alkenylene; C 5 -C 10 cycloalkylene; C 5 -C 10 arylene; or C 5 -C 10 arylene-C 1 -C 10 alkylene; Y is the residue of an organic dye which corresponds to the formula (1a), wherein R 2 is hydrogen; or C 1 -C 5 alkyl; R 3 is a radical of formula (1a 1 ): (1a 2 ); or (1a 3 ); or R 2 and R 3 together with the linking carbon atom 1 C form a 6 to 10 membered carbocyclic ring which may optionally be a condensated aromatic system and may contain one or more than one hetero atom; and R 4 , R 5 and R 6 independently form each other are hydrogen, or C 1 -C 5 alkyl; Z is H; or a thio ester group of formula (1b), wherein A is O; S; or N—R9; B is —OR7; —NR7R8, or —SR7; and A is O; S; or N—R 9 ; B is —OR 7 ; —NR 7 R 8 , or —SR 7 ; and R 7 , R 8 and R 9 , independently from each other are hydrogen; C 1 -C 12 alkyl C 6 -C 12 aryl; or C 6 -C 12 aryl-C 1 -C 12 alkyl. The compounds are useful for the dyeing of organic materials, such as keratin fibers, preferably human hair.

  揭示了式（1）的硫醇染料，其中R1为氢；C1-C12烷基；或苯基-C1-C4烷基；X为C1-C12亚烷基；C2-C12烯亚烷基；C5-C10环烷基；C5-C10芳基；或C5-C10芳基-C1-C10亚烷基；Y为与式（1a）对应的有机染料的残基，其中R2为氢；或C1-C5烷基；R3为式（1a1）的基团：（1a2）；或（1a3）；或R2和R3与连接碳原子1C形成6至10成员的碳环，该碳环可以选择性地是一个缩合芳香系统，并且可以含有一个或多个杂原子；以及R4，R5和R6独立地形成彼此为氢，或C1-C5烷基；Z为H；或式（1b）的硫酯基团，其中A为O；S；或N—R9；B为—OR7；—NR7R8，或—SR7；而A为O；S；或N—R9；B为—OR7；—NR7R8，或—SR7；且R7，R8和R9，彼此独立地为氢；C1-C12烷基；C6-C12芳基；或C6-C12芳基-C1-C12烷基。这些化合物适用于有机材料的染色，例如角蛋白纤维，最好是人类头发。
• Sun protection compositions comprising semi-crystalline polymers and hollow latex particles
  申请人：Candau Didier

  公开号：US20090041691A1

  公开（公告）日：2009-02-12

  Topically applicable cosmetic/dermatological UV protection compositions having enhanced SPF contain at least one organic UV screening agent and/or at least one inorganic screening agent, such compositions also containing at least the following constituents (A) and (B): A) a semi-crystalline polymer which is solid at ambient temperature and has a melting point of greater than or equal to 30° C., containing a) a polymeric backbone and b) at least one crystallizable organic side chain and/or one crystallizable organic block forming part of the backbone of this said polymer, said polymer having a number-average molecular mass Mn of greater than or equal to 1,000, and B) hollow latex particles having a particle size ranging from 150 to 380 nm, formulated into a topically applicable, physiologically acceptable medium therefor.

  具有增强SPF的适用于化妆品/皮肤科的防紫外线保护组合物至少包含一种有机紫外线过滤剂和/或至少一种无机过滤剂，此类组合物还至少包含以下成分（A）和（B）： A）半结晶聚合物，室温下为固体，熔点大于或等于30°C，包含a）聚合骨架和b）至少一种可结晶有机侧链和/或作为该聚合物骨架一部分的可结晶有机块，该聚合物具有大于或等于1,000的数均分子质量Mn，以及 B）中空乳胶颗粒，粒径范围为150至380纳米，配制成适用于局部使用的、生理上可接受的介质。
• COSMETIC TREATMENT METHOD USING A COMPOUND THAT CAN BE CONDENSED IN SITU AND A UV-RADIATION-FILTERING AGENT
  申请人：Samain Henri

  公开号：US20120328542A1

  公开（公告）日：2012-12-27

  The present invention relates to a method for the cosmetic treatment of the skin, comprising the application, to the skin: of a compound or group of compounds A capable of condensing in situ and exhibiting at least one reactive functional group F A which is free after condensation; and of a screening agent C which screens out UV radiation, comprising a reactive functional group F C capable of forming a covalent bond or a physical (ionic, hydrogen) bond by reaction with the functional group F A .

  本发明涉及一种用于皮肤美容治疗的方法，包括将以下物质应用于皮肤： 一种或一组化合物A，能够在原位缩合并具有至少一个反应性功能基团F A ，在缩合后是自由的；以及 一种用于屏蔽紫外线辐射的筛选剂C，包括一个具有反应性功能基团F C 的物质，能够通过与功能基团F A 的反应形成共价键或物理（离子、氢）键。
• COMPOSITION COMPRISING A DIBENZOYLMETHANE SCREENING AGENT AND A MEROCYANINE DICYANO OR CYANOACETATE DERIVATIVE; METHOD FOR THE PHOTOSTABILIZATION OF THE DIBENZOYLMETHANE SCREENING AGENT
  申请人：L'OREAL

  公开号：US20150284330A1

  公开（公告）日：2015-10-08

  The present invention relates to a cosmetic composition comprising the combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one specific merocyanine dicyano or cyanoacetate derivative. It also relates to a method for the photostabilization, with regard to radiation, of at least one screening agent of the dibenzoylmethane derivative type by an effective amount of at least one specific merocyanine dicyano or cyanoacetate derivative.

  本发明涉及一种化妆品组合物，包括i)至少一种二苯甲酮衍生物型筛选剂的组合和ii)至少一种特定的梅洛氰二氰或氰乙酸酯衍生物。它还涉及一种方法，通过有效量的至少一种特定的梅洛氰二氰或氰乙酸酯衍生物，对至少一种二苯甲酮衍生物型筛选剂进行光稳定化处理，以抵御辐射。
• Cosmetic/sunscreen compositions containing dibenzoylmethane compounds and dithiolane compound photostabilizers therefor
  申请人：Lucet-Levannier Karine

  公开号：US20100086502A1

  公开（公告）日：2010-04-08

  Cosmetic/sunscreen compositions contain a combination of at least one dibenzoylmethane sunscreen compound and a photostabilizing amount of at least one dithiolane compound of formula (I) below:

  化妆品/防晒霜组合物含有至少一种二苯甲酮类防晒剂化合物和至少一种式（I）所示的二硫杂环化合物的光稳定量。