3-allyl-4-allyloxytoluene | 51496-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-allyl-4-allyloxytoluene
• 英文别名: 2-(Prop-2-enyl)-4-(prop-2-enyloxy)toluol；allyl-(2-allyl-4-methyl-phenyl)-ether；Allyl-(2-allyl-4-methyl-phenyl)-aether；4-Allyloxy-1-methyl-3-allyl-benzol；4-Methyl-2-(prop-2-en-1-yl)-1-[(prop-2-en-1-yl)oxy]benzene；4-methyl-1-prop-2-enoxy-2-prop-2-enylbenzene
• CAS: 51496-25-4
• 化学式: C₁₃H₁₆O
• 分子量: 188.269
• InChiKey: AJDYVOMUNGEHRT-UHFFFAOYSA-N

物化性质

• 沸点：
  265.1±9.0 °C(Predicted)
• 密度：
  0.930±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-allyl-4-allyloxytoluene 在 palladium 10% on activated carbon 、 氢气 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 生成 2,6-dipropyl-4-methylphenol
  参考文献：
  名称：

  “三重奏杰克”-强大的一锅金属无酚苯胺氧化，叠氮化和过氧化反应†

  摘要：

  本文中，我们公开了一种通过苯酚的胺化和叠氮化氧化脱芳香化反应生成含氮季碳中心的高效方法。相同的方案也已成功用于实现酚的氧化过氧化。最简单的无金属反应条件表明了对“三重奏”的轻松突破-氧化胺化，叠氮化和过氧化。在一个罐中已合成了多种多样的多官能化杂环。

  DOI：

  10.1039/c7nj00169j
• 作为产物：
  描述：

  烯丙基对甲苯醚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 10.0h， 生成 3-allyl-4-allyloxytoluene
  参考文献：
  名称：

  烯丙基酚作为一类新的人类 15-脂氧合酶-1 抑制剂

  摘要：

  在这项研究中，设计、合成了一系列单烯丙基苯酚和二烯丙基苯酚衍生物，并对其作为潜在的人类 15-脂氧合酶-1 (15-hLOX-1) 抑制剂进行了评估。评估了合成烯丙基苯酚衍生物的自由基清除效力，结果与脂氧合酶 (LOX) 抑制效力一致。发现烯丙基部分和对位取代基的电子性质在自由基清除活性和随后合成抑制剂的 LOX 抑制效力中起主要作用。在合成化合物中，2,6-二烯丙基-4-(己氧基)苯酚 ( 42 ) 和 2,6-二烯丙基-4-氨基苯酚 ( 47 ) 对 LOX 的抑制效果最好（IC 50 = 0.88 和 0.80 μM，分别为）。

  DOI：

  10.1002/ddr.21749

文献信息

• A New One-Pot Synthetic Approach to the Highly Functionalized (<i>Z</i>)-2-(Buta-1,3-dienyl)phenols and 2-Methyl-2<i>H</i>-chromenes: Use of Amine, Ruthenium and Base-Catalysis
  作者：Dhevalapally B. Ramachary、Vidadala V. Narayana、Kinthada Ramakumar

  DOI：10.1002/ejoc.200800472

  日期：2008.8

  (Z)-2-(buta-1,3-dienyl)phenols 6 and 2-methyl-2H-chromenes 7 from simple starting materials was achieved for the first time through ring-closing metathesis/base-induced ring opening/[1,7]-sigmatropic hydrogen shift reactions. The synthesis of privileged (Z)-2-(buta-1,3-dienyl)phenols 6 via base-induced ring opening of highly functionalized benzo[b]oxepines 5 is described(© Wiley-VCH Verlag GmbH &

  一种用于合成高度取代的苯并[b]氧杂环庚烷 5、(Z)-2-(buta-1,3-dienyl)phenols 6 和 2-methyl-2H-chromenes 7 的实用且简单的一锅多催化工艺首次通过闭环复分解/碱诱导开环/[1,7]-σ-σ 氢位移反应从简单的起始材料中获得。描述了通过碱诱导的高度官能化苯并 [b] 氧杂环庚烷 5 开环合成特权 (Z)-2-(buta-1,3-dienyl)phenols 6 (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 魏因海姆，德国，2008）
• THIOL COMPOUNDS, SYNTHESIS METHOD THEREFOR, AND UTILIZATION OF SAID THIOL COMPOUNDS
  申请人：SHIKOKU CHEMICALS CORPORATION

  公开号：US20200369606A1

  公开（公告）日：2020-11-26

  The purpose of the present invention is to provide: novel thiol compounds; a method for synthesizing said thiol compounds; curing agents containing said thiol compounds; resin compositions containing said thiol compounds and an epoxy compound; and resin compositions containing said thiol compounds and an ene compound having a carbon-carbon double bond in a molecule. Furthermore, the purpose of the present invention is to provide adhesives and sealants having these resin compositions as ingredients. The thiol compounds of the present invention are represented by chemical formula (I) to chemical formula (VII).

  本发明的目的是提供：新型硫醇化合物；合成该硫醇化合物的方法；含有该硫醇化合物的固化剂；含有该硫醇化合物和环氧化合物的树脂组合物；以及含有该硫醇化合物和分子中含有碳碳双键的烯烃化合物的树脂组合物。此外，本发明的目的是提供将这些树脂组合物作为成分的粘合剂和密封剂。本发明的硫醇化合物由化学式(I)到化学式(VII)表示。
• Modification of enteral diets in inflammatory bowel disease
  作者：Marian C. Aldhous、Doris Meister、Subrata Meister

  DOI：10.1079/pns2001120

  日期：2001.11

  The provision of food is thought to promote the maintenance of gut integrity. Nutrients are able to elicit and affect both systemic and mucosal immune responses. Enteral diet therapy has long been known to be efficacious in inflammatory bowel disease (IBD), particularly in childhood Crohn's disease. However, the mechanisms of action of these diets are not clear. Nutritional repletion, direct effects on the gut mucosa or decreased intestinal permeability have all been postulated as being important in nutritional therapy. There is some evidence that the enteral diet has a direct effect on the gut mucosa by reducing cytokine production and the accompanying inflammation, thus leading to decreased intestinal permeability. Modifications of enteral diet composition have been evaluated in many studies. Such modifications include fat and/or protein content and the addition of bioactive peptides. The fatty acid composition of the enteral diet seems to have a much greater impact on its efficacy than modification of the N source. As specific fatty acids are precursors of inflammatory mediators derived from arachidonic acid, the reduction in these components may be beneficial in nutritional therapy for IBD. Addition of bioactive peptides to enteral diet formulas may also have a role; such peptides may have specific growth factor or anti-inflammatory actions. There is still much work to be done to define disease-specific enteral diet formulas that are effective as therapies for both Crohn's disease and ulcerative colitis.

  人们认为，提供食物可以促进肠道完整性的维护。营养物质能够引起并影响全身和粘膜免疫反应。肠内饮食疗法对炎症性肠病（IBD），尤其是儿童克罗恩病（Crohn's disease）的疗效早已众所周知。然而，这些饮食的作用机制尚不清楚。营养补充、对肠道粘膜的直接影响或肠道渗透性的降低都被认为是营养疗法的重要作用。有证据表明，肠内饮食可通过减少细胞因子的产生和伴随的炎症对肠道粘膜产生直接影响，从而降低肠道渗透性。许多研究对肠内饮食成分的调整进行了评估。这些改变包括脂肪和/或蛋白质含量以及添加生物活性肽。与 N 来源的改变相比，肠内饮食的脂肪酸组成对其疗效的影响似乎更大。由于特定脂肪酸是由花生四烯酸衍生的炎症介质的前体，因此减少这些成分可能有利于 IBD 的营养治疗。在肠内饮食配方中添加生物活性肽可能也有一定作用；这类肽可能具有特定的生长因子或抗炎作用。要确定能有效治疗克罗恩病和溃疡性结肠炎的特定疾病肠道饮食配方，还有很多工作要做。
• Claisen; Eisleb, Justus Liebigs Annalen der Chemie, 1913, vol. 401, p. 44
  作者：Claisen、Eisleb

  DOI：——

  日期：——
• A New Synthesis of Substituted 2,5-Dihydrobenzo[b]oxepines
  作者：Eng-Chi Wang、Ming-Kun Hsu、Yu-Li Lin、Keng-Shiang Huang

  DOI：10.3987/com-02-9545

  日期：——

  Based on Claisen rearrangement, Baeyer-Villiger oxidation, and ring-closing metathesis (RCM), a series of substituted 2,5-dihydrobenzo[b]oxepines were synthesized from isovanillin in good over-all yields. Other appropriate substituted 2,5-dihydrobenzo[b]oxepines prepared from corresponding phenol derivatives were also described.