4-acetyl-heptanenitrile | 55320-41-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-acetyl-heptanenitrile
• 英文别名: 4-Acetyl-heptannitril；5-Oxo-4-propyl-hexansaeure-(1)-nitril；4-Acetyl-oenanthonitril；4-Acetyl-6-cyan-hexan；Heptanenitrile, 4-acetyl-；4-acetylheptanenitrile
• CAS: 55320-41-7
• 化学式: C₉H₁₅NO
• 分子量: 153.224
• InChiKey: QFLFYMSAKSBTEL-UHFFFAOYSA-N

物化性质

• 沸点：
  110 °C(Press: 5-6 Torr)
• 密度：
  0.9037 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-acetyl-heptanenitrile 在 盐酸 、 sodium methylate 作用下， 生成 4-丙基-1,3-环己烷二酮
  参考文献：
  名称：

  Kost,A.N.; Ovseneva,L.G., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3908 - 3911

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 4-acetyl-heptanenitrile
  参考文献：
  名称：

  Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α-Galactosyl IgG antibodies

  摘要：

  Abstract: Natural α‐Galactosyl (Gal) antibodies play an important role in the rejection of pig xenografts by humans and Old World monkeys. In this study we investigate the efficacy of two different strategies to reduce the serum level of natural anti‐Gal antibodies. On the one hand, removal of aerobic gram‐negative bacteria from the intestinal flora, because anti‐Gal antibodies appear to be produced as a result of the continuous sensitization by these microorganisms. On the other hand, we studied the effect on these antibodies of an immunosuppressive regimen of cyclophosphamide and steroids. Ten baboons were treated for three months with norfloxacin (Nor Group; n = 6) or cyclophosphamide and steroids (CyP Group; n = 4). A further four baboons did not receive any treatment (Control Group). Aerobic gram‐negative bacteria became negative in stools of the Nor Group after two weeks of treatment, and remained undetectable until week 7. Thereafter, a gradual increase on the fecal concentration of aerobic gram‐negative bacteria was observed despite the norfloxacin treatment. The mean anti‐Gal IgG in the Nor Group gradually declined from week 4 to 9 to a mean of 62.7 ± 18% of the baseline level, and during this period were significantly lower than in the CyP (P < 0.02) and the Control (P < 0.05) groups. No differences were observed between the three groups during the 16 weeks of follow‐up in serum levels of anti‐Gal IgM, hemolytic anti‐pig antibodies, total IgG, IgM and IgA. In conclusion, removal of normal aerobic gram‐negative bacteria from the intestinal flora is more effective than immunosuppression with CyP and steroids in reducing the level of natural anti‐Gal antibodies, although there is no discernible effect on IgM antibodies.

  DOI：

  10.1034/j.1399-3089.2001.00082.x

文献信息

• Kost,A.N.; Ovseneva,L.G., Journal of general chemistry of the USSR, 1962, vol. 32, p. 3908 - 3911
  作者：Kost,A.N.、Ovseneva,L.G.

  DOI：——

  日期：——
• Schuscherina et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 398,400, 401; engl. Ausg. S. 401, 402, 403
  作者：Schuscherina et al.

  DOI：——

  日期：——
• Zhang Zhen-Quan, Gao Shi-Ping, Sun Qiang, Sun Yun-Hong, Mao Li-Juan, Youji huaxue (Org. Chem), 13 (1993) N 6, S 623-626
  作者：Zhang Zhen-Quan, Gao Shi-Ping, Sun Qiang, Sun Yun-Hong, Mao Li-Juan

  DOI：——

  日期：——
• Fadda; El-Houssini, Journal of the Indian Chemical Society, 1990, vol. 67, # 11, p. 915 - 917
  作者：Fadda、El-Houssini

  DOI：——

  日期：——
• Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α-Galactosyl IgG antibodies
  作者：Rafael Mañez、Francisco J. Blanco、Inmaculada Díaz、Alberto Centeno、Eduardo Lopez-Pelaez、Manuel Hermida、Hugh F. S. Davies、Andreas Katopodis

  DOI：10.1034/j.1399-3089.2001.00082.x

  日期：2001.2

  Abstract: Natural α‐Galactosyl (Gal) antibodies play an important role in the rejection of pig xenografts by humans and Old World monkeys. In this study we investigate the efficacy of two different strategies to reduce the serum level of natural anti‐Gal antibodies. On the one hand, removal of aerobic gram‐negative bacteria from the intestinal flora, because anti‐Gal antibodies appear to be produced as a result of the continuous sensitization by these microorganisms. On the other hand, we studied the effect on these antibodies of an immunosuppressive regimen of cyclophosphamide and steroids. Ten baboons were treated for three months with norfloxacin (Nor Group; n = 6) or cyclophosphamide and steroids (CyP Group; n = 4). A further four baboons did not receive any treatment (Control Group). Aerobic gram‐negative bacteria became negative in stools of the Nor Group after two weeks of treatment, and remained undetectable until week 7. Thereafter, a gradual increase on the fecal concentration of aerobic gram‐negative bacteria was observed despite the norfloxacin treatment. The mean anti‐Gal IgG in the Nor Group gradually declined from week 4 to 9 to a mean of 62.7 ± 18% of the baseline level, and during this period were significantly lower than in the CyP (P < 0.02) and the Control (P < 0.05) groups. No differences were observed between the three groups during the 16 weeks of follow‐up in serum levels of anti‐Gal IgM, hemolytic anti‐pig antibodies, total IgG, IgM and IgA. In conclusion, removal of normal aerobic gram‐negative bacteria from the intestinal flora is more effective than immunosuppression with CyP and steroids in reducing the level of natural anti‐Gal antibodies, although there is no discernible effect on IgM antibodies.