trans-2-(2-phenylethyl)clohexanol | 36449-64-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trans-2-(2-phenylethyl)clohexanol
• 英文别名: (+/-)-trans-2-phenethyl-cyclohexanol；(+/-)-trans-2-Phenaethyl-cyclohexanol；(+/-)-trans-Phenaethyl-cyclohexanol-(2)
• CAS: 36449-64-6；139389-31-4
• 化学式: C₁₄H₂₀O
• 分子量: 204.312
• InChiKey: XZWKIBGRBMDUAD-KGLIPLIRSA-N

物化性质

• 熔点：
  17-18 °C
• 沸点：
  158-160 °C(Press: 6 Torr)
• 密度：
  1.012±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.17
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  trans-2-(2-phenylethyl)clohexanol 在 sodium azide 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 trans-1-azido-2-(2-phenylethyl)cyclohexane
  参考文献：
  名称：

  2-Amino-2-oxazolines as Subtype Selective α₂ Adrenoceptor Agonists

  摘要：

  Cyclohexylamino oxazoline 1 (AGN 190837), an analogue of 2 (Bay a6781), is a potent alpha(2) adrenoceptor agonist, On the basis of a design generated by receptor-ligand modeling, a number of cyclohexyl and norbornyl analogues were synthesized wherein the propyl group of 1 was replaced by phenylalkyl subsituents. This resulted in compound 6 being an alpha(2c) selective agonist, as well as 7 and 9 being alpha(2a)/alpha(2c) selective.

  DOI：

  10.1021/jm9905256
• 作为产物：
  描述：

  lithium phenylacetylide 在 乙醚 、 乙醇 、 铂 作用下， 生成 trans-2-(2-phenylethyl)clohexanol
  参考文献：
  名称：

  The Cyclization of Optically Active 2-(2-Phenylethyl)-cyclohexanol

  摘要：

  DOI：

  10.1021/ja01596a074

文献信息

• Differential Transfer Benefits of Increased Practice for Constant, Blocked, and Serial Practice Schedules
  作者：Clare G. Giuffrida、John B. Shea、Jeffrey T. Fairbrother

  DOI：10.1080/00222890209601953

  日期：2002.12

  The effects of practice schedule and amount of practice on the development of the generalized motor program (GMP) and on parameter estimation were investigated. Participants (N = 108) practiced the same relative timing but different absolute durations of a multisegment timing task. Practice schedules (constant, blocked, or serial) were crossed with amounts of practice (low and high). Inclusion of a constant practice condition allowed the authors to investigate the variability of practice prediction. Participants practiced the same proportional durations in a serial or a blocked schedule, which enabled the authors to examine contextual interference. A constant practice schedule enhanced GMP performance when task parameters remained the same, but varied practice schedules were beneficial when task parameters changed. A serial as opposed to a blocked practice schedule was superior when the performance of a task governed by a different GMP was required. Increased practice led to a consolidated task representation that was unavailable for updating.