5-chloro-2-(4-chlorophenyl)-1H-indole-3-carbaldehyde | 104384-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-chloro-2-(4-chlorophenyl)-1H-indole-3-carbaldehyde
• 英文别名: 5-chloro-2-(4-chlorophenyl)-1H-indole-3-carboxaldehyde
• CAS: 104384-25-0
• 化学式: C₁₅H₉Cl₂NO
• 分子量: 290.149
• InChiKey: JTFJWIKYZGJBSC-UHFFFAOYSA-N

物化性质

• 沸点：
  512.9±50.0 °C(Predicted)
• 密度：
  1.431±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-chloro-2-(4-chlorophenyl)-1H-indole-3-carbaldehyde 、 氨基硫脲 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以71%的产率得到2-((5-chloro-2-(4-chlorophenyl)-1H-indol-3-yl)methylene)hydrazine-1-carbothioamide
  参考文献：
  名称：

  Saundane; Manjunatha, Yarlakatti; Walmik, Prabhaker, Heterocyclic Communications, 2009, vol. 15, # 4, p. 303 - 310

  摘要：

  DOI：
• 作为产物：
  描述：

  5-chloro-2-(4-chlorophenyl)indole 、 、 sodium hydroxide 、 、 N,N-二甲基甲酰胺 在 水 作用下， 反应 16.0h， 以to give the title compound as an orange solid (3.05 g, 88%)的产率得到5-chloro-2-(4-chlorophenyl)-1H-indole-3-carbaldehyde
  参考文献：
  名称：

  2-aryl indole derivatives and their use as therapeutic agents

  摘要：

  本发明涉及公式（I）的化合物：其中R1a，R1b和R2表示各种取代基；R3表示可选取代的苯基，联苯基或萘基或杂环芳基；R4表示氢，C1-6烷基，羰基(=O)，（CH2）pphenyl或C1-2烷基桥接到哌啶环上；R5和R6各自独立地表示各种取代基；或R5和R6连在一起形成可选取代的5或6元环；X表示氧或硫原子，两个氢原子，═NH或═N（C1-6烷基）；Y是直链或支链C1-4烷基，C2-4烯基或C2-4炔基链；虚线表示可选的双键；m为零或1到4的整数；n为1到4的整数；p为1到4的整数；或其药学上可接受的盐。该化合物特别适用于治疗或预防抑郁症、焦虑症、疼痛、炎症、偏头痛、呕吐或带状疱疹后神经痛。

  公开号：

  US20010039286A1

文献信息

• 2-aryl indole derivatives and their use as therapeutic agents
  申请人：——

  公开号：US20010039286A1

  公开（公告）日：2001-11-08

  The present invention relates compounds of the formula (I): 1 wherein R 1a , R 1b ; and R 2 represent a variety of substituents; R 3 represents an optionally substituted phenyl, biphenyl or naphthyl or heteroaryl group; R 4 represents hydrogen, C 1-6 alkyl, carbonyl (=O), (CH 2 ) p phenyl or a C 1-2 alkylene bridge across the piperidine ring; R 5 and R 6 each independently represent a variety of substituents; or R 5 and R 6 together are linked so as to form an optionally substituted 5-or 6-membered ring; X represents an oxygen or a sulfur atom, two hydrogen atoms, ═NH or ═N(C 1-6 alkyl); Y is a straight or branched C 1-4 alkylene, C 2-4 alkenylene or C 2-4 alkynylene chain; the dotted line represents an optional double bond; m is zero or an integer from 1 to 4; n is an integer from 1 to 4; and p is an integer from 1 to 4; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia.

  本发明涉及以下式（I）的化合物： 1 其中 R 1a ，R 1b ; 和 R 2 代表各种取代基; R 3 代表可选择地取代的苯基、联苯基或萘基或杂环芳基; R 4 代表氢、C 1-6 烷基、羰基（=O）、（CH 2 ） p 苯基或穿过哌啶环的 C 1-2 烷基桥; R 5 和 R 6 各自独立地代表各种取代基; 或 R 5 和 R 6 一起连接以形成可选择地取代的5-或6-成员环; X代表氧或硫原子、两个氢原子、═NH或═N(C 1-6 烷基); Y是直链或支链C 1-4 烷基、C 2-4 烯基或C 2-4 炔基链; 虚线表示可选的双键; m为零或1至4的整数; n为1至4的整数; p为1至4的整数; 或其药学上可接受的盐。 这些化合物在治疗或预防抑郁症、焦虑、疼痛、炎症、偏头痛、呕吐或带状疱疹后神经痛方面特别有用。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• Triarylimidazoles-synthesis of 3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives as potent α-glucosidase inhibitors
  作者：Sadia Naureen、Shazia Noreen、Areesha Nazeer、Muhammad Ashraf、Umber Alam、Munawar Ali Munawar、Misbahul Ain Khan

  DOI：10.1007/s00044-014-1239-y

  日期：2015.4

  A series of new trisubstituted imidazoles-3-(4,5-diaryl-1H-imidazol-2-yl)-2-phenyl-1H-indole derivatives (2a-2u) were synthesized and evaluated for their alpha-glucosidase inhibition. The new compounds showed significant alpha-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined using FT-IR, Mass spectrometry, H-1 NMR, C-13 NMR, and elemental analyses.
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577B1

  公开（公告）日：2018-12-12
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.